Figure 2. Phylogenetic tree (neighbor-joining method) of hepatitis E virus (HEV) genotype 3 isolates for a 273-nt sequence within the open reading frame 2 gene (corresponding to nt 6078–6350 of the prototype swine genotype 3 pSHEV-3 AY 575859). Patient (EF050798) and pet pig (EF050797) sequences are in boldface and were compared with French isolates or known isolates from regions where HEV is not endemic. GenBank accession no. and country of origin are indicated. Reliability of the different phylogenetic grouping was evaluated by using a bootstrap test (1,000 replications); scores >70% are indicated. Scale bar indicates no. of nucleotide substitutions per site. SP, Spain; FR, France; NL, the Netherlands; JP, Japan; USA, United States; UK, United Kingdom.