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Volume 13, Number 7—July 2007

Research

Virulence Characteristics of Klebsiella and Clinical Manifestations of K. pneumoniae Bloodstream Infections

Victor L. Yu*Comments to Author , Dennis S. Hansen†, Wen Chien Ko‡, Asia Sagnimeni*, Keith P. Klugman§, Herman Goossens#, Marilyn M. Wagener*, Vicente J. Benedi**1, Meningeal Disease Surveillance in South Africa¶, and the International Klebsiella Study Group

Author affiliations: *University of Pittsburgh, Pittsburgh, Pennsylvania, USA; †Statens Serum Institut, Copenhagen, Denmark; ‡National Cheng Kung University Medical College, Tainan, Taiwan, Republic of China; §Emory University, Atlanta, Georgia, USA; ¶South African Institute of Medical Research, Johannesburg, South Africa; #University Hospital, Antwerp, Belgium; **Universidad de las Islas Baleares, Palma de Mallorca, Spain;

Main Article

Table 1

Disease type by virulence factor*

Source of organism and type of infection K1 or K2 
serotype, % Mucoid 
phenotype, % Aerobactin 
producer, % Mouse 
mortality rate, %†
Taiwan
Community-acquired 28 (22/80) 56 (45/80) 54 (43/80) 46
Hospital-acquired 17 (2/12) 25 (3/12) 33 (4/12) 29
South Africa
Community-acquired 46 (16/35) 60 (21/35) 63 (22/35) 52
Hospital-acquired 16 (4/25) 16 (4/25) 8 (2/25) 0
Rest of world
Community-acquired 4 (1/26) 0 (0/26) 4 (1.26) 0
Hospital-acquired 5 (2/36) 8 (3/36) 8 (3/36) 0

*Note the virtual absence of putative virulence factors in strains from the rest of the world, other than Taiwan and South Africa. See Results for p values.
†2 mice were tested for each available strain.

Main Article

1Deceased.

2The International Klebsiella Study Group comprises the previously named authors plus Jose Maria Casellas, Gordon Trenholme, Joseph McCormack, Sunita Mohapatra, and Lutfiye Mulazimoglu.

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