Volume 13, Number 8—August 2007
Research
Infection with Scedosporium apiospermum and S. prolificans, Australia
Louise Cooley*†, Denis Spelman*, Karin Thursky‡, and Monica Slavin*‡
Table 2
Characteristics of 8 patients with invasive disease and Scedospoeium prolificans infections, Australia, 1997–2003*
| Patient no. | Primary disease | Transplant type | Neutropenia within 30 d | GVHD | Date of first isolate | Days post transplant | Initial symptom | Site of isolates | Outcome following diagnosis |
|---|---|---|---|---|---|---|---|---|---|
| 1 | ALL | Allogeneic HSCT | Yes | Chronic extensive | Aug 2000 | >400 | Knee effusion | Blood, synovium, cartilage, prostate | Died d 21 |
| 2 | AML | Allogeneic HSCT | No | Chronic extensive | Apr 2001 | >500 | Pulmonary infiltrate | Blood, sputum, BAL, lung | Died d 5 |
| 3 | MM | Allogeneic HSCT | Yes | No | Nov 2000 | 28 | Ethmoid sinus infiltrate | Ethmoid sinus, vertebral disc, mycotic aneurysm | Alive d 500 |
| 4 | NHL | Allogeneic HSCT | Yes | No | Dec 2000 | 10 | Neutropenic sepsis | Blood | Died before diagnosis |
| 5 | AML | Allogeneic HSCT | Yes | No | Mar 2003 | 10 | Neutropenic sepsis | Blood, sputum, BAL, lung, skin | Died d 1 |
| 6 | MM | Allogeneic HSCT | Yes | Chronic extensive | Nov 2002 | 120 | Pneumonia | Sputum | Died d 1 |
| 7 | MDS | NA | No | NA | Nov 2003 | NA | Maxillary sinus infiltrate | Sputum, maxillary sinus, pericardium, myocardium, kidney, skin, lung | Died d 14 |
| 8 | AML | NA | Yes | NA | May 2002 | NA | Catheter-related sepsis | Chest wall, Hickman catheter | Alive d 500 |
*GVHD, graft versus host disease; ALL, acute lymphoblastic leukemia; HSCT, hematopoietic stem cell transplantation; AML, acute myeloid leukemia; BAL, bronchoalveolar lavage; MM, multiple myeloma; NHL, non-Hodgkin lymphoma; MDS, myelodysplastic syndrome; NA, not applicable because patients did not undergo stem cell transplantation.
