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Volume 13, Number 8—August 2007


Risk Factors for Colonization with Extended-Spectrum β-Lactamase–producing Bacteria and Intensive Care Unit Admission

Anthony D. Harris*†Comments to Author , Jessina C. McGregor*, Judith A. Johnson*†, Sandra M. Strauss*, Anita C. Moore*, Harold C. Standiford‡, Joan N. Hebden‡, and J. Glenn Morris*
Author affiliations: *University of Maryland, Baltimore, Maryland, USA; †Veterans Affairs Maryland Health Care System, Baltimore, Maryland, USA; ‡University of Maryland Medical Center, Baltimore, Maryland, USA;

Main Article

Table 1

Potential predictors of colonization by an ESBL-producing bacterium on ICU admission*

Potential predictorNo. ESBL colonized
(n = 117)No. not ESBL colonized
(n = 5,092)p value†
Age, y (median, IQR)62 (49–71)56 (45–67)<0.01
CDS (median, IQR)8 (5–10)8 (5–10)0.20
CDS-ID (median, IQR)3.21 (1.83–4.78)2.83 (1.83–3.40)<0.01
Sex, female, no. (%)59 (50)2,311 (45)0.30
Antimicrobial drug exposures, no. (%)‡
Quinolone18 (15)617 (12)0.32
1st-generation cephalosporin9 (8)559 (11)0.30
3rd-generation cephalosporin7 (6)293 (6)0.84
Vancomycin34 (29)616 (12)<0.01
Aminoglycoside11 (9)366 (7)0.36
Piperacillin-tazobactam50 (43)1,090 (21)<0.01
Cefepime9 (8)161 (3)0.01
Imipenem11 (9)224 (4)0.02

*ESBL, extended-spectrum β-lactamase; ICU, intensive care unit; IQR, interquartile range; CDS, Chronic Disease Score; CDS-ID, infectious disease–specific CDS.
†Fisher exact test for dichotomous predictors and Wilcoxon test for continuous predictors.
‡Antimicrobial drug exposures that occurred during the index hospital admission but before ICU admission.

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