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Volume 13, Number 9—September 2007


Detecting Human-to-Human Transmission of Avian Influenza A (H5N1)

Yang Yang*, M. Elizabeth Halloran*†, Jonathan D. Sugimoto*†, and Ira M. Longini*†Comments to Author 
Author affiliations: *Fred Hutchinson Cancer Research Center, Seattle, Washington, USA; †University of Washington, Seattle, Washington, USA;

Main Article


Parameters and data used in analysis

Category Parameter/data Required*
Entire outbreak Outbreak begin date X
Outbreak end date X
Latent/incubation period, d† X
Infectious period, d† X
All persons Neighborhood of residence X
Household of residence X
Sex X
Age, y X
Case status (yes or no) X
Case-patients Whether outbreak index case-patient (yes or no) X
Date of illness onset X
Outcome (recovered, died, or don’t know/still ill) X
Date of outcome X
Dates of hospitalization O
Period of receiving treatment (dates) O
Non–case-patients Dates of hospitalization O
Period of prophylactic treatment (dates) O
Inter-residence visits Identifier for visiting person X
Neighborhood visited X
Household visited X
Dates of the visit X
Analysis parameters End of exposure to the common source of infection (date) X
Final day of observation (date) X
R0 estimation Mean no. residents per household X‡
Mean no. community contacts per person/d X‡

*X, required; O, optional; R0, basic reproduction number.
†The user defines the distribution of this period, including the minimum and maximum length of the period.
‡Required to estimate R0.

Main Article

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