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Volume 14, Number 10—October 2008


Prophylaxis after Exposure to Coxiella burnetii

Claire E. MoodieComments to Author , Herbert A. Thompson, Martin I. Meltzer, and David L. Swerdlow
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA;

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Table 2

Probability of adverse events associated with postexposure prophylactic antimicrobial agents

Level of adverse event Doxycycline*
Best estimate Upper bound† Best estimate Upper bound
Moderate 1.01% 3.03% 3.90% 11%
Severe 0.01% 0.03% 0.00123% 0.00370%‡
Death 0.00% 0.01% 0.00037% 0.00111%

*Recommended for the general population and high-risk populations based on estimated use of 100 mg orally 2×/d for 5 d.
†Recommended for pregnant women based on 160 mg/800 mg orally 2×/d for the duration of the pregnancy.
‡Arbitrary upper-bound, 3× best estimate (see text for further details).

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