Emerging Infectious Disease ISSN: 1080-6059

Genetic Characterization of Toggenburg Orbivirus, a New Bluetongue Virus, from Goats, Switzerland

Martin A. Hofmann

, Sandra Renzullo, Markus Mader, Valérie Chaignat, Gabriella Worwa, and Barbara Thuer

Author affiliations: Institute of Virology and Immunoprophylaxis, Mittelhaeusern, Switzerland

Figure 3

Phylogenetic analysis of Toggenburg orbivirus (TOV) (shaded regions) genome segments by ClustalW alignment (16) and subsequent neighbor-joining tree construction by MEGA version 4 software (15). GenBank accession numbers are indicated for all orbivirus sequences used to construct dendrograms. A) Segment 5; B) segment 6; C) segment 7; D) segment 8; E) segment 9; F) segment 10. BTV, bluetongue virus; EHDV, epizootic hemorrhagic disease virus. Segments show only relevant parts of dendrograms. **Segment 10 sequence of BTV-8 currently circulating in northern Europe. Scale bars indicate number of nucleotide substitutions per site.

Figure 3. Phylogenetic analysis of Toggenburg orbivirus (TOV) (shaded regions) genome segments by ClustalW alignment (16) and subsequent neighbor-joining tree construction by MEGA version 4 software (15). GenBank accession numbers are indicated for all orbivirus sequences used to construct dendrograms. A) Segment 5; B) segment 6; C) segment 7; D) segment 8; E) segment 9; F) segment 10. BTV, bluetongue virus; EHDV, epizootic hemorrhagic disease virus. Segments show only relevant parts of dendrograms. **Segment 10 sequence of BTV-8 currently circulating in northern Europe. Scale bars indicate number of nucleotide substitutions per site.

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