Volume 14, Number 2—February 2008
Research
Severe Streptococcus pyogenes Infections, United Kingdom, 2003–2004
Theresa L. Lamagni*
, Shona Neal*, Catherine Keshishian*, Neelam Alhaddad*, Robert C. George*, Georgia Duckworth*, Jaana Vuopio-Varkila†, and Androulla Efstratiou*
, Shona Neal*, Catherine Keshishian*, Neelam Alhaddad*, Robert C. George*, Georgia Duckworth*, Jaana Vuopio-Varkila†, and Androulla Efstratiou*Table 2
Clinical markers of severe Streptococcus pyogenes infection in the United Kingdom, 2003–2004*
| Marker | All case-patients (n = 2,611), no. (%) | Bacteremia with no defined focus (n = 558), no. (%) | Pneumonia (n = 309), no. (%) | Cellulitis (n = 881), no. (%) | Septic arthritis (n = 220), no. (%) | Necrotizing fasciitis (n = 136), no. (%) | Puerperal sepsis (n = 58), no. (%) |
|---|---|---|---|---|---|---|---|
| Clinical severity (n = 2,611) | |||||||
| Hypotensive shock | 494 (19) | 101 (18) | 70 (23) | 155 (18) | 43 (20) | 80 (59) | 13 (22) |
| STSS (hypotension + >2 listed below) | 196 (8) | 28 (5) | 27 (9) | 63 (7) | 18 (8) | 55 (40) | 3 (5) |
| Renal impairment | 381 (15) | 69 (12) | 50 (16) | 149 (17) | 40 (18) | 58 (43) | 3 (5) |
| Respiratory distress | 288 (11) | 41 (7) | 113 (37) | 67 (8) | 20 (9) | 33 (24) | 1 (2) |
| Erythematous rash | 231 (9) | 30 (5) | 15 (5) | 135 (15) | 13 (6) | 17 (13) | 4 (7) |
| Soft-tissue necrosis | 254 (10) | 0 | 8 (3) | 116 (13) | 13 (6) | 136 (100) | 3 (5) |
| Liver abnormality | 185 (7) | 31 (6) | 23 (7) | 65 (7) | 14 (6) | 31 (23) | 3 (5) |
| Disseminated intravascular coagulation | 131 (5) | 21 (4) | 14 (5) | 40 (5) | 10 (5) | 35 (26) | 6 (10) |
| Admission to ICU (n = 2,292) | 451 (20) | 76 (16) | 68 (24) | 136 (17) | 40 (21) | 101 (77) | 8 (16) |
| Surgical intervention (n = 1,885) | 443 (24) | 21 (6) | 19 (8) | 131 (20) | 106 (63) | 106 (87) | 10 (24) |
| Death within 7 d (n = 2,192) | 413 (19) | 97 (22) | 87 (32) | 121 (16) | 17 (9) | 43 (34) | 2 (4) |
*STSS, streptococcal toxic shock syndrome; ICU, intensive care unit.
