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Volume 14, Number 3—March 2008

Research

Multicenter Cross-Sectional Study of Nontuberculous Mycobacterial Infections among Cystic Fibrosis Patients, Israel

Isaac Levy*1, Galia Grisaru-Soen*12, Liat Lerner-Geva†, Eitan Kerem‡, Hana Blau§, Lea Bentur¶, Micha Aviram#, Joseph Rivlin**, Elie Picard††, Anita Lavy‡‡, Yakov Yahav*, and Galia Rahav*Comments to Author 
Author affiliations: *Sheba Medical Center, Tel Hashomer, Israel; †Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, Israel; ‡Hadassah Hebrew University Hospital, Jerusalem, Israel; §Schneider Children’s Medical Center of Israel, Petah Tikva, Israel; ¶Rambam Medical Center, Haifa, Israel; #Soroka University Hospital, Beer Sheva, Israel; **Carmel Medical Center, Haifa, Israel; ††Shaare Zedek Medical Center, Jerusalem, Israel; ‡‡Mycobacterium Reference Laboratory of Israel, Tel Aviv, Israel; 1These authors contributed equally to this work.; 2Current affiliation: Dana Children’s Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.;

Main Article

Table 2

Comparison of patients included in the current study, patients tested for NTM, and patients not tested for NTM*

Parameter Patients included in the current study (n = 186) Patients tested for
NTM (n = 265) Patients not tested for NTM (n = 203) p value
Age (mean ± SD) 20.51 ± 10.40 20.22 ± 10.53 13.99 ± 10.70 0.0001
Sex, F/M 74/112 105/160 86/117 0.54
Hemoptysis 22 23 4 0.002
FEV1, L/s (mean ± SD) 67.90 ± 22.09 65.18 ± 21.69 82.94 ± 16.20 0.0001
Pancreatic insufficiency 135 151 131 0.09
Hospitalization, d (mean ± SD) 21.77 ± 28.54 23.80 ± 32.44 8.44 ± 14.03 0.0001
Administration of antimicrobial agents, d (mean ± SD) 22.66 ± 47.51 19.98 ± 45.52 2.30 ± 10.28 0.0001
Azithromycin 104 114 51 0.001
Ibuprofen 7 15 6 0.16
Insulin 17 20 9 0.16
Systemic steroids 13 37 19 0.12
Inhaled steroids 96 106 105 0.01

*NTM, nontuberculous mycobacteria; SD, standard deviation; FEV1, forced expiratory volume in 1 s.

Main Article

1These authors contributed equally to this work.

2Current affiliation: Dana Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

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