Emerging Infectious Disease ISSN: 1080-6059

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Multicenter Cross-Sectional Study of Nontuberculous Mycobacterial Infections among Cystic Fibrosis Patients, Israel

Isaac Levy*¹, Galia Grisaru-Soen*¹², Liat Lerner-Geva†, Eitan Kerem‡, Hana Blau§, Lea Bentur¶, Micha Aviram#, Joseph Rivlin**, Elie Picard††, Anita Lavy‡‡, Yakov Yahav*, and Galia Rahav*

Author affiliations: *Sheba Medical Center, Tel Hashomer, Israel; †Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, Israel; ‡Hadassah Hebrew University Hospital, Jerusalem, Israel; §Schneider Children’s Medical Center of Israel, Petah Tikva, Israel; ¶Rambam Medical Center, Haifa, Israel; #Soroka University Hospital, Beer Sheva, Israel; **Carmel Medical Center, Haifa, Israel; ††Shaare Zedek Medical Center, Jerusalem, Israel; ‡‡Mycobacterium Reference Laboratory of Israel, Tel Aviv, Israel; 1These authors contributed equally to this work.; 2Current affiliation: Dana Children’s Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.;

Main Article

Table 2

Comparison of patients included in the current study, patients tested for NTM, and patients not tested for NTM*

Parameter	Patients included in the current study (n = 186)	Patients tested for NTM (n = 265)	Patients not tested for NTM (n = 203)	p value
Age (mean ± SD)	20.51 ± 10.40	20.22 ± 10.53	13.99 ± 10.70	0.0001
Sex, F/M	74/112	105/160	86/117	0.54
Hemoptysis	22	23	4	0.002
FEV₁, L/s (mean ± SD)	67.90 ± 22.09	65.18 ± 21.69	82.94 ± 16.20	0.0001
Pancreatic insufficiency	135	151	131	0.09
Hospitalization, d (mean ± SD)	21.77 ± 28.54	23.80 ± 32.44	8.44 ± 14.03	0.0001
Administration of antimicrobial agents, d (mean ± SD)	22.66 ± 47.51	19.98 ± 45.52	2.30 ± 10.28	0.0001
Azithromycin	104	114	51	0.001
Ibuprofen	7	15	6	0.16
Insulin	17	20	9	0.16
Systemic steroids	13	37	19	0.12
Inhaled steroids	96	106	105	0.01