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Volume 14, Number 3—March 2008

Research

Hantavirus RNA in Saliva from Patients with Hemorrhagic Fever with Renal Syndrome

Lisa Pettersson*, Jonas Klingström*†‡, Jonas Hardestam†‡, Åke Lundkvist†‡, Clas Ahlm*, and Magnus Evander*Comments to Author 
Author affiliations: *Umeå University, Umeå, Sweden; †Swedish Institute for Infectious Disease Control, Solna, Sweden; ‡Karolinska Institutet, Stockholm, Sweden;

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Table

Comparison between detection of PUUV RNA in saliva and plasma and antibodies in serum samples from 14 patients with nephropathia epidemica*

Patient no. Sex Age, y Date saliva collected (d of disease) PUUV RNA† in saliva, copies/mL PUUV RNA† in plasma,‡ copies/mL PUUV IgM§ in serum‡ PUUV IgG titer in serum‡
1 M 65 6 121,323 959,294 + 40
2 M 64 2 66,994 117,562 + 80
3 M 33 5 44,898 40,427 + >640
4 F 38 6 17,516 1,381,413 + 40
5 F 59 9 9,582 3,724 + >640
6 M 54 5 6,372 26,626 320
7 M 39 7 3,745 189,233 + 320
8 M 28 5 2,589 36,231 + >640
9 F 26 5 2,163 54,315 + 80
10 F 39 5 1,530 3,044 + 80
11 M 38 6 0 1,952 ± >640
12 M 41 6 0 5,215 + 40
13 F 57 2 0 41,271 + 320
14 F 62 7 0 81,330 + 160

*PUUV, Puumala virus; Ig, immunoglobulin.
†Detected by real-time reverse transcription–PCR.
‡Most plasma and serum samples were collected the same day or within 1 day before or after the saliva sample and antibody was detected by immunofluorescence assay.
§Serum was diluted 1:16 and scored as negative (–), positive (+), or weakly positive (±).

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