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Volume 14, Number 4—April 2008

Research

Determination of Oseltamivir Quality by Colorimetric and Liquid Chromatographic Methods

Michael D. Green*Comments to Author , Henry Nettey*, and Robert A. Wirtz*
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA;

Main Article

Table 1

Accuracy and precision for the high-performance liquid chromatographic (HPLC) and colorimetric assays (n = 5)

Nominal concentration, mg/mL Accuracy, %
Precision, %
Interday Intraday Interday Intraday
HPLC
0.6 –10.8 –10.3 9.0 7.9
1.5 –8.4 0.4 7.3 2.3
2.4 5.0 –0.7 7.3 5.7
3.0 0.4 1.6 4.9 4.8
3.6 0.7 4.4 4.1 3.6
4.5
–0.9
–3.2

2.5
2.5
Congo red colorimetric
1.5 2.0 2.2 12.5 2.3
2.4 2.6 –0.3 9.2 6.9
3.0 –5.5 1.0 6.5 5.4
3.6 0.7 1.2 3.7 3.8
4.5
1.0
–0.1

2.6
1.3
Bromochlorophenol blue colorimetric
6.0 –5.3 –19.4 18.6 12.4
9.6 0.0 3.4 13.5 2.6
12.0 2.7 10.4 6.1 5.9
14.4 3.5 3.2 4.3 3.8
18.0 –2.9 –5.4 4.9 3.0

Main Article

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