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Volume 14, Number 4—April 2008
Research

Determination of Oseltamivir Quality by Colorimetric and Liquid Chromatographic Methods

Michael D. Green*Comments to Author , Henry Nettey*, and Robert A. Wirtz*
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA;

Main Article

Table 1

Accuracy and precision for the high-performance liquid chromatographic (HPLC) and colorimetric assays (n = 5)

Nominal concentration, mg/mL Accuracy, %
Precision, %
Interday Intraday Interday Intraday
HPLC
0.6 –10.8 –10.3 9.0 7.9
1.5 –8.4 0.4 7.3 2.3
2.4 5.0 –0.7 7.3 5.7
3.0 0.4 1.6 4.9 4.8
3.6 0.7 4.4 4.1 3.6
4.5
–0.9
–3.2

2.5
2.5
Congo red colorimetric
1.5 2.0 2.2 12.5 2.3
2.4 2.6 –0.3 9.2 6.9
3.0 –5.5 1.0 6.5 5.4
3.6 0.7 1.2 3.7 3.8
4.5
1.0
–0.1

2.6
1.3
Bromochlorophenol blue colorimetric
6.0 –5.3 –19.4 18.6 12.4
9.6 0.0 3.4 13.5 2.6
12.0 2.7 10.4 6.1 5.9
14.4 3.5 3.2 4.3 3.8
18.0 –2.9 –5.4 4.9 3.0

Main Article

Page created: July 09, 2010
Page updated: July 09, 2010
Page reviewed: July 09, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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