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Volume 14, Number 4—April 2008

Research

Determination of Oseltamivir Quality by Colorimetric and Liquid Chromatographic Methods

Michael D. Green*Comments to Author , Henry Nettey*, and Robert A. Wirtz*
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA;

Main Article

Table 2

Evaluation of oseltamivir products purchased over the Internet*

Brand HPLC Congo red Bromochlorophenol blue
A 94 ± 1 95 ± 3 106 ± 4
B 87 ± 2 88 ± 3 97 ± 8
C 94 ± 4 93 ± 2 103 ± 3
D 96 ± 1 93 ± 5 107 ± 7
E 97 ± 3 89 ± 3 104 ± 5
F 95 ± 0 88 ± 2 101 ± 3

*HPLC, high-performance liquid chromatography. Values are the percentage of active ingredient found per capsule relative to that stated on the manufacturer’s package insert (average ±SD; n = 3 capsules).

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