Volume 14, Number 4—April 2008
Research
Determination of Oseltamivir Quality by Colorimetric and Liquid Chromatographic Methods
Michael D. Green*
, Henry Nettey*, and Robert A. Wirtz*
, Henry Nettey*, and Robert A. Wirtz*Table 2
Evaluation of oseltamivir products purchased over the Internet*
| Brand | HPLC | Congo red | Bromochlorophenol blue |
|---|---|---|---|
| A | 94 ± 1 | 95 ± 3 | 106 ± 4 |
| B | 87 ± 2 | 88 ± 3 | 97 ± 8 |
| C | 94 ± 4 | 93 ± 2 | 103 ± 3 |
| D | 96 ± 1 | 93 ± 5 | 107 ± 7 |
| E | 97 ± 3 | 89 ± 3 | 104 ± 5 |
| F | 95 ± 0 | 88 ± 2 | 101 ± 3 |
*HPLC, high-performance liquid chromatography. Values are the percentage of active ingredient found per capsule relative to that stated on the manufacturer’s package insert (average ±SD; n = 3 capsules).
