Emerging Infectious Disease ISSN: 1080-6059

Single Nucleotide Polymorphism Typing of Bacillus anthracis from Sverdlovsk Tissue

Richard T. Okinaka*†, Melinda Henrie*, Karen K. Hill*, KristinS. Lowery‡, Matthew Van Ert†, Talima Pearson†, James Schupp†, Leo Kenefic†, Jodi Beaudry†, Steven A. Hofstadler‡, Paul J. Jackson*§, and Paul Keim*†¶

Author affiliations: *Los Alamos National Laboratory, Los Alamos, New Mexico, USA; †Northern Arizona University, Flagstaff, Arizona, USA; ‡Ibis Biosciences Inc, Carlsbad, California, USA; §Lawrence Livermore National Laboratory, Livermore, California, USA; ¶Translational Genomics Research Institute, Phoenix, Arizona, USA;

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Figure

Schematic single nucleotide polymorphism (SNP) tree for Bacillus anthracis. This tree illustrates the relative positions of several sequenced strains of B. anthracis that form the specific sublineages in the A group of B. anthracis and in particular the Western North American lineage (A.BR.WNA, represented by a blue star [10]). The canonical SNPs and their positions are depicted in red lettering. A branch point (red circle) or node designated A.Br.008/009 originally represented 154 isolates and canSNP analysis places Sverdlovsk 7.RA93.15.15 in this node. The new pagA SNP981 defines a new branch radiating from this node and contains at least 3 other isolates.

Figure. Schematic single nucleotide polymorphism (SNP) tree for Bacillus anthracis. This tree illustrates the relative positions of several sequenced strains of B. anthracis that form the specific sublineages in the A group of B. anthracis and in particular the Western North American lineage (A.BR.WNA, represented by a blue star [10]). The canonical SNPs and their positions are depicted in red lettering. A branch point (red circle) or node designated A.Br.008/009 originally represented 154 isolates and canSNP analysis places Sverdlovsk 7.RA93.15.15 in this node. The new pagA SNP981 defines a new branch radiating from this node and contains at least 3 other isolates.

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