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Volume 14, Number 4—April 2008
Research

Clonal Population of Flucytosine-Resistant Candida tropicalis from Blood Cultures, Paris, France

Marie Desnos-Ollivier*, Stéphane Bretagne*†, Claire Bernède*‡, Vincent Robert§, Dorothée Raoux*, Elisabeth Chachaty¶, Elisabeth Forget#, Claire Lacroix**, Françoise Dromer*Comments to Author , and the YEASTS group
Author affiliations: *Institut Pasteur, Paris, France; †Hôpital Henri Mondor–Assistance Publique Hôpitaux de Paris, Créteil, France; ‡Institut Pasteur Institut National de la Santé et de la Recherche Médicale Unité 657, Paris, France; §Centraal Bureau voor Schimmelcultures, Utrecht, the Netherlands; ¶Institut Gustave-Roussy, Villejuif, France; #Hôpital Beaujon, Clichy, France; **Hôpital Saint Louis, Paris, France;

Main Article

Table 2

Comprehensive analysis of 30 Candida tropicalis isolates*

Strain no. 5FC MIC (μg/mL) Month of 
isolation SNP
ITS2 PMM alleles
 MLST
 URA3
base 529
URA3 CT14 MDR1 XYR1 SAPT4
ODL1–18 >64 2002 Nov – 178/178 148/151 20 26 10 G
ODL1–40 >64 2002 Nov – 178/178 148/151 20 26 10 G
ODL1–41 >64 2002 Nov – 178/178 148/151 20 26 10 G
ODL1–53 16 2002 Dec – 178/178 148/151 20 26 10 G
ODL2–105 >64 2003 Mar – 178/178 148/151 20 26 10 G
ODL2–198 32 2003 Jul – 178/178 148/151 20 26 10 G
ODL2–199 >64 2003 Jul – 178/178 148/151 20 26 10 G
ODL3–237 >64 2003 Sep – 178/178 148/151 18 26 10 G
ODL3–293 >64 2003 Oct – 178/178 148/151 20 26 10 G
ODL4–311 >64 2003 Sep – 178/178 148/151 20 26 10 G
ODL4–328 >64 2003 Nov – 178/178 148/151 20 26 10 G
ODL4–341 >64 2003 Nov – 178/178 148/151 20 26 10 G
ODL5–426 >64 2003 Dec – 178/178 148/151 20 26 10 G
ODL6–558 32 2004 Apr – 178/178 148/151 20 26 10 G
ODL1–58 <0.125 2003 Jan + 176/176 148/148 24 30 7 A
ODL3–211 0.25 2003 Jul + 174/178 148/148 1 79 1 A-G†
ODL3–231 <0.125 2003 Sep – 176/176 151/151 66 9 18 A
ODL4–302 0.25 2003 Sep – 176/178 148/151 4 36 23 A
ODL4–347 0.25 2003 Nov + 174/174 151/154 7 52 6 A
ODL4–384 0.5 2003 Dec – 174/176 151/151 67 4 19 A
ODL5–460 <0.125 2004 Feb + 174/178 148/148 68 76 36 A-G†
ODL5–474 <0.125 2004 Mar + 174/174 154/154 7 52 6 A
ODL5–476 <0.125 2004 Mar + 178/178 151/151 27 4 11 A
ODL5–485 <0.125 2004 Mar – 176/178 148/157 22 41 7 A
ODL5–488 <0.125 2004 Apr + 176/178 148/151 25 24 7 A
ODL6–504 <0.125 2004 Feb + 174/178 148/151 22 9 38 A
ODL6–511 <0.125 2004 Apr + 174/178 148/148 1 80 1 A-G†
ODL6–521 <0.125 2004 May + 176/178 148/151 69 77 41 A
ODL6–539 <0.125 2004 Mar + 174/174 148/154 58 48 13 A
ODL6–560 <0.125 2004 Jul – 178/178 148/151 4 36 23 A
CBS94 <0.125 – + 176/176 148/148 70 78 5 A

*5FC, flucytosine; SNP, single nucleotide polymorphism; ITS2, internal transcribed spacer 2; PMM, polymorphic microsatellites marker; MLST, multilocus sequence typing (boldface corresponds to new alleles).
†A-G heterozygous.

Main Article

1The YEASTS group is composed of (in alphabetical order by city): Claire Bouges-Michel (Hôpital Avicenne, Bobigny), Isabelle Poilane (Hôpital Jean Verdier, Bondy), Marie-Elisabeth Bougnoux, Jean Dunand (Hôpital Ambroise Paré, Boulogne), Guy Galeazzi (Hôpital Louis Mourier, Colombes), Stéphane Bretagne, Françoise Botterel (Hôpital Henri Mondor, Créteil), Nathalie Fauchet (Centre Hospitalier Intercommunal de Créteil, Créteil), Elisabeth Forget (Hôpital Beaujon, Clichy), Françoise Botterel, Christine Bonnal (Hôpital du Kremlin Bicêtre), Odile Eloy (Hôpital Mignot, Le Chesnay), Christine Lawrence (Hôpital Raymond Poincaré, Garches), Marie-Françoise David, Liliana Mihaila (Hôpital Paul Brousse, Villejuif), Elisabeth Chachaty, Olivier Adam (Institut Gustave Roussy, Villejuif), and in Paris: Christian Chochillon (Hôpital Bichat), André Paugam, Marie-Thérèse Baixench (Hôpital Cochin), Muriel Cornet (Hôpital de l’Hôtel Dieu), Marie-Christine Escande (Institut Curie), Svetlana Challier, Marie-Elisabeth Bougnoux (Hôpital Necker), Eric Dannaoui (Hôpital Européen Georges Pompidou), Annick Datry, Houria Laklache, Bader Lmimouni, Sophie Brun (Hôpital de la Pitié-Salpétrière), Jean-Louis Poirot (Hôpital Saint Antoine), Claire Lacroix (Hôpital Saint Louis), Didier Moissenet (Hôpital Trousseau), Michel Develoux (Hôpital Tenon), and Stéphane Bonacorsi (Hôpital Robert Debré).

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