Volume 14, Number 4—April 2008
Research
Hemorrhagic Fever with Renal Syndrome Caused by 2 Lineages of Dobrava Hantavirus, Russia1
Boris Klempa*†2, Evgeniy A. Tkachenko‡2, Tamara K. Dzagurova‡, Yulia V. Yunicheva‡, Vyacheslav G. Morozov‡, Natalia M. Okulova‡, Galina P. Slyusareva‡, Aleksey Smirnov‡, and Detlev H. Kruger*
Table 3
Severity of clinical disease for 126 patients with Dobrava-Belgrade–associated hemorrhagic fever with renal syndrome, Russia*
| Characteristic | Severity† |
||
|---|---|---|---|
| Mild | Moderate | Severe | |
| Clinical sign or symptom | |||
| Maximum temperature, °C | <38.0 | 38.0–39.5 | >39.5 |
| Headache | –/+ | +/++ | +++/++++ |
| Vision disturbance | – | –/+ | +/++ |
| Low-back, abdominal pain | –/+ | +/++ | +++/++++ |
| Hemorrhagic (petechial) skin rash | – | –/+ | –/+/++ |
| Oliguria (minimum mL/d) | >900 | 300–900 | <200–300 |
| Oliguria duration, d | 6 | 9 | 11–13 |
| Maximum blood urea, mmol/L | <8.3 | 8.3–19.0 | >19.0 |
| Maximum blood creatinine, μmol/L | <130 | 130–300 | >300 |
| Maximum leukocyte count, 109/L |
<8.0 |
8.0–14.0 |
>14.0 |
| Clinical outcome by region | |||
| Sochi (2000–2006) | 6% | 39% | 55% |
| Lipetsk (2001–02) | 19% | 54% | 27% |
*Boldface indicates statistically significant differences between groups. Comparison of binomial population proportions analysis implemented in Statlets (NWP Associates, Inc.; www.mrs.umn.edu/~sungurea/statlets/statlets.htm) indicates that the null hypothesis that the 2 proportions are equal could be rejected at significance level of 5.0%.
†According to Leshchinskaia et al. (34).
1This work is dedicated to the memory of our friend and colleague Milan Labuda, who died in August 2007.
