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Volume 14, Number 4—April 2008

Research

Hemorrhagic Fever with Renal Syndrome Caused by 2 Lineages of Dobrava Hantavirus, Russia1

Boris Klempa*†2, Evgeniy A. Tkachenko‡2, Tamara K. Dzagurova‡, Yulia V. Yunicheva‡, Vyacheslav G. Morozov‡, Natalia M. Okulova‡, Galina P. Slyusareva‡, Aleksey Smirnov‡, and Detlev H. Kruger*Comments to Author 

Author affiliations: *Charité School of Medicine, Berlin, Germany; †Slovak Academy of Sciences, Bratislava, Slovakia; ‡Russian Academy of Medical Sciences, Moscow, Russia;

Main Article

Table 3

Severity of clinical disease for 126 patients with Dobrava-Belgrade–associated hemorrhagic fever with renal syndrome, Russia*

Characteristic Severity†
Mild Moderate Severe
Clinical sign or symptom
Maximum temperature, °C <38.0 38.0–39.5 >39.5
Headache –/+ +/++ +++/++++
Vision disturbance –/+ +/++
Low-back, abdominal pain –/+ +/++ +++/++++
Hemorrhagic (petechial) skin rash –/+ –/+/++
Oliguria (minimum mL/d) >900 300–900 <200–300
Oliguria duration, d 6 9 11–13
Maximum blood urea, mmol/L <8.3 8.3–19.0 >19.0
Maximum blood creatinine, μmol/L <130 130–300 >300
Maximum leukocyte count, 109/L
<8.0
8.0–14.0
>14.0
Clinical outcome by region
Sochi (2000–2006) 6% 39% 55%
Lipetsk (2001–02) 19% 54% 27%

*Boldface indicates statistically significant differences between groups. Comparison of binomial population proportions analysis implemented in Statlets (NWP Associates, Inc.; www.mrs.umn.edu/~sungurea/statlets/statlets.htm) indicates that the null hypothesis that the 2 proportions are equal could be rejected at significance level of 5.0%.
†According to Leshchinskaia et al. (34).

Main Article

1This work is dedicated to the memory of our friend and colleague Milan Labuda, who died in August 2007.

2These authors contributed equally to this article.

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