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Volume 14, Number 6—June 2008

Research

Validation of Syndromic Surveillance for Respiratory Pathogen Activity

Cees van den Wijngaard*Comments to Author , Liselotte van Asten*, Wilfrid van Pelt*, Nico J.D. Nagelkerke†, Robert Verheij‡, Albert J. de Neeling*, Arnold Dekkers*, Marianne A.B. van der Sande*, Hans van Vliet*, and Marion P.G. Koopmans*
Author affiliations: *National Institute for Public Health and the Environment, Bilthoven, the Netherlands; †United Arab Emirates University, Al-Ain, United Arab Emirates; ‡Netherlands Institute of Health Services Research, Utrecht, the Netherlands;

Main Article

Table 6

Standardized parameter estimates (βs) for all respiratory pathogen counts included as explanatory variables in the regression models: before and after adding seasonal terms to the models*†

Syndrome data RSV Influenza A Influenza B S. pneumoniae (residual) RV PIV Adenovirus Enterovirus Mycoplasma pneumoniae Bordetella pertussis
Absenteeism 0.31/ (NS) 0.27/ (NS) 0.33/
(NS) 0.28/
0.12 0.19/ (NS) 0.20/ (NS) _ _ _
GP 0.60/ 0.51 0.32/
0.32 0.20/
0.16 0.13/
0.10 0.07/ (NS) 0.14/ 0.08 0.07/
(NS) _ 0.06/
0.05 _
Pharmacy 0.51/ 0.54 0.27/
0.22 0.24/
(NS) 0.25/
0.11 0.16/ 0.08 0.16/ (NS) 0.08/
(NS) _ 0.12/
(NS) 0.11/
0.11
Hospitalization 0.60/ 0.44 0.36/
0.34 0.21/
0.12 _ 0.13/ 0.05 0.09/ (NS) _ _ _ _
Laboratory submissions 0.49/ 0.47 0.19/
0.20 0.22/
0.18 0.28/
0.22 _ 0.17/ 0.08 _ _ 0.10/
0.10 _
Mortality 0.40/ 0.36 0.52/
0.51 0.24/
0.24 _ _ _ _ _ _ _

*S. pneumoniae, Streptococcus pneumoniae; RSV, respiratory syncytial virus; RV, rhinovirus; PIV, parainfluenza virus; GP, general practice; –, pathogen not included in model; NS, the pathogen variable is no longer significant after seasonal terms are added.
†For example, 0.60/0.40 for RSV indicates a standardized β of 0.60 for RSV in the model with only pathogen variables and a β of 0.40 in the same model after adding seasonal terms.

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