Emerging Infectious Disease ISSN: 1080-6059

Diversity and Origin of Dengue Virus Serotypes 1, 2, and 3, Bhutan

Tandin Dorji, In-Kyu Yoon, Edward C. Holmes, Sonam Wangchuk, Tashi Tobgay, Ananda Nisalak, Piyawan Chinnawirotpisan, Kanittha Sangkachantaranon, Robert V. Gibbons, and Richard G. Jarman

Author affiliations: Ministry of Health, Thimphu, Bhutan (T. Dorji, S. Wangchuk); United States Army Medical Command–Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand (I.-K. Yoon, A. Nisalak, P. Chinnawirotpisan, K. Sangkachantaranon, R.V. Gibbons, R.G. Jarman); The Pennsylvania State University, University Park, Pennsylvania, USA (E.C. Holmes); National Institutes of Health, Bethesda, Maryland, USA (E.C. Holmes); Ministry of Health, Gelephu, Bhutan (T. Tobgay).

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Figure 2

A) Maximum-likelihood phylogenetic tree of 264 complete envelope gene sequences of dengue virus serotype 3 (DENV-3). The different genotypes of DENV-3 and the isolates from Bhutan (red) are indicated. Scale bar indicates number of substitutions per site. B) Magnification of the part of the phylogeny where the Bhutan sequences (red) fall. The tree is midpoint rooted for clarity only, and all horizontal branch lengths are drawn to a scale of nucleotide substitutions per site. Bootstrap support val

Figure 2. A) Maximum-likelihood phylogenetic tree of 264 complete envelope gene sequences of dengue virus serotype 3 (DENV-3). The different genotypes of DENV-3 and the isolates from Bhutan (red) are indicated. Scale bar indicates number of substitutions per site. B) Magnification of the part of the phylogeny where the Bhutan sequences (red) fall. The tree is midpoint rooted for clarity only, and all horizontal branch lengths are drawn to a scale of nucleotide substitutions per site. Bootstrap support values are shown for key nodes only.

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