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Volume 15, Number 10—October 2009

Research

Nosocomial Outbreak of Novel Arenavirus Infection, Southern Africa

Janusz T. Paweska, Nivesh H. Sewlall, Thomas G. Ksiazek, Lucille H. Blumberg, Martin J. Hale, W. Ian Lipkin, Jacqueline Weyer, Stuart T. Nichol, Pierre E. Rollin, Laura K. McMullan, Christopher D. Paddock, Thomas Briese, Joy Mnyaluza, Thu-Ha Dinh, Victor Mukonka, Pamela Ching, Adriano Duse, Guy Richards, Gillian de Jong, Cheryl Cohen, Bridget Ikalafeng, Charles Mugero, Chika Asomugha, Mirriam M. Malotle, Dorothy M. Nteo, Eunice Misiani, Robert SwanepoelComments to Author , Sherif R. Zaki, Investigation Teams1, and members of the Outbreak Control
Author affiliations: National Institute for Communicable Diseases, Sandringham, South Africa (J.T. Paweska, L.H. Blumberg, J. Weyer, G de Jong, C. Cohen, R. Swanepoel); University of the Witwatersrand, Johannesburg, South Africa (N.H. Sewlall, M.J. Hale, A. Duse); Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA (T.G. Ksiazek, S.T. Nichol, P.E. Rollin, L.K. McMullan, C.D. Paddock, T.-H. Dinh, S.R. Zaki); Columbia University, New York, New York, USA (W.I. Lipkin, T. Briese); Gauteng Department of Health, Johannesburg (J. Mnyaluza, B. Ikalafeng, C. Asomugha); CDC Global AIDS Program, Pretoria, South Africa (T.-H. Dinh); Ministry of Health, Lusaka, Zambia (V. Mukonka); CDC Global AIDS Program, Lusaka (P. Ching); Charlotte Maxeke Hospital, Johannesburg (G. Richards); National Department of Health, Pretoria (C. Mugero, E. Misiani); Field Epidemiology and Laboratory Training Programme, Johannesburg (M.M. Malotle, D.M. Nteo); University of Texas Medical Branch, Galveston, Texas, USA (T.G. Ksiasek)

Main Article

Table

Summary of diagnostic RT-PCR and virus isolation studies on 5 novel arena virus–infected patients, southern Africa, 2008*

Patient no. Onset of illness Date sampled Day of illness sampled Sample type RT-PCR Virus isolation
1 Sep 2 Sep 12 11 Blood + +
2 Sep 21 Sep 25 5 Blood +
2 Sep 21 Sep 29 9 Blood +
2 Sep 21 Sep 30 10 Blood +
2 Sep 21 Oct 9 12† Liver + +
3 Sep 23 Oct 3 11 Blood +
3 Sep 23 Oct 9 13† Liver + +
4 Sep 27 Oct 6 10 Blood + +
5 Oct 9 Oct 10 2 Blood + +

*Chronology of testing samples differs from the order in which they were collected from patients. RT-PCR, reverse transcription–PCR; +, positive; –, negative.
†Refers to day of illness on which the patient died.

Main Article

1Members of the Outbreak Control and Investigation Teams: F. Abrahams, T. Aseko, F.G. Benson, M. Bush, D. Cannon, A. Cengimbo, G. Chetty, L. Chibesakunda, C. Chisembele, J.A. Comer, A. Craig, C. De Meyer, J. Erasmus, S.M. Dickerson, E. Farnon, A.A. Grobbelaar, A. Hayward, M. Hoohlo, P. Jansen van Vuren, A. Kemp, G. Kocher, J. Koethe, P.A. Leman, W. Lubinda, R. Lynen, C. Malibata, A. Marumo, B. Matapo, T.J. Meade, D. Miller, M. Monze, V.C. Mtonga, P. Mwaba, A. Mweene, M. Naidu, T. Nemungadi, C. Oranmore-Brown, C.S. Pak, R.M. Phillips, W. Ramakrishna, Z. Reed, S. Ri, G. Richards, K. Robinson, C. Smith, G. Sharp, G.B. Song, L. van der Walt, C. Villar, L. Wamunyima.

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