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Volume 15, Number 12—December 2009

Research

Genomic Signatures of Influenza A Pandemic (H1N1) 2009 Virus

Guang-Wu ChenComments to Author  and Shin-Ru Shih
Author affiliations: Chang Gung University, Taoyuan, Taiwan, Republic of China

Main Article

Table 2

Amino acid residues of pandemic (H1N1) 2009 virus strains at 8 positions where swine–human signatures are located*

Gene Position Swine virus residue (all subtypes) Human virus residue Pandemic (H1N1) 2009 virus residue
PB2
44
A(301), S(27), C(1)
S(2,734), A(30), L(2)
A(61)
PA 268 L(325), I(31), T(1) I(2,724), L(35), V(2) L(61)

552
T(280), S(25)
S(2,721), T(10), N(2), I(1), R(1)
T(61)
M1
137
T(429), A(39)
A(3,577), T(25)
T(146)
M2 57 Y(343), H(23), R(2) H(3,804),Y(65), D(25), Q(5), R(5), N(4) Y(55)
86 V(324), A(24), S(1) A(3,781), V(26), T(10), D(1) V(55)

93
N(320), S(23)
S(3,699), N(69), Q(2), R(1), H(1), I(1)
N(55)
NS2 107 L(299), F(25) F(2,850), L(45), S(1), V(1) L(93)

*Boldface indicates dominant amino acid residue type. PB, polymerase B; PA, polymerase A; M, matrix; NS, nonstructural.

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