Volume 15, Number 3—March 2009
CME ACTIVITY
Clinical Risk Factors for Severe Clostridium difficile–associated Disease
Timothy J. Henrich
, Douglas Krakower, Asaf Bitton, and Deborah S. Yokoe
, Douglas Krakower, Asaf Bitton, and Deborah S. YokoeTable 5
Binary logistic regression model to identify independent associations of laboratory values and pertinent variables with severe CDAD, 285 patients*
| Variable | OR | 95% CI |
|---|---|---|
| Age >70 y | 3.24† | 1.42–7.38 |
| Female | 1.16 | 0.51–2.62 |
| Antimicrobial-drug use | 1.04 | 0.35–3.12 |
| Malignancy | 0.90 | 0.37–2.18 |
| Chemotherapy | 1.02 | 0.27–3.92 |
| Steroid use | 1.13 | 0.48–2.68 |
| Hemodialysis | 0.5 | 0.8–3.01 |
| Max leukocyte count >20,000/μL | 2.77† | 1.28–6.0 |
| Max glucose level >150 mg/dL | 1.46 | 0.63–3.43 |
| ALT >40 U/L | 1.47 | 0.58–3.69 |
| Min albumin level <2.5 g/dL | 3.44† | 1.56–7.57 |
| Max creatinine level >2 mg/dL | 2.47† | 1.04–5.88 |
*CDAD, Clostridium difficile–associated disease; OR, odds ratio; CI, confidence interval; max, maximum; ALT, alanine aminotransferase; min, minimum. Constant included in analysis.
†p<0.05.
