Volume 15, Number 4—April 2009
Research
Novel Type of Streptococcus pneumoniae Causing Multidrug-Resistant Acute Otitis Media in Children
Qingfu Xu, Michael E. Pichichero, Janet R. Casey, and Mingtao Zeng
Table 1
Genotypic characteristics of Streptococcus pneumoniae serotype 19A strains with multiple antimicrobial drug resistance*
| Strain | Sequence type | MIC, µg/mL |
Allele no. of housekeeping genes† |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pen | Cef | Ery | S.Tri | aroE | gdh | gki | recP | spi | xpt | ddl | |||
| P270CR | 320 | 2.0 | 1.0 | >256 | >32 | 4 | 16 | 19 | 15 | 6 | 20 | 1 | |
| 060110 | 1451 | 4.0 | 1.0 | >256 | 4.0 | 10 | 16 | 19 | 15 | 6 | 20 | 1 | |
| P270CL | 320 | 2.0 | 1.0 | >256 | >32 | 4 | 16 | 19 | 15 | 6 | 20 | 1 | |
| Legacy strain | 2722‡ | 8.0 | 6.0 | 8.0 | >32 | 7 | 11 | 10 | 15 | 6 | 8 | 1 | |
| P239CR | 320 | 2.0 | 2.0 | >256 | 8.0 | 4 | 16 | 19 | 5 | 6 | 20 | 1 | |
| 0601034 | 320 | 2.0 | 1.0 | >256 | 16.0 | 4 | 16 | 19 | 15 | 6 | 20 | 1 | |
| 0601004V1NW | 320 | 2.0 | 1.5 | >256 | 6.0 | 4 | 16 | 19 | 15 | 6 | 20 | 1 | |
| 0601004V1LMEF | 320 | 3.0 | 1.5 | >256 | 4.0 | 4 | 16 | 19 | 15 | 6 | 20 | 1 | |
*Pen, benzylpenicillin; Cef, ceftriaxone; Ery, erythromycin; S.Tri, sulfamethoxazole-trimethoprim.
†aroE (shikimate dehydrogenase), gdh (glucose-6-phosphate dehydrogenase), gki (glucose kinase), recP (transketolase), spi (signal peptidase I), xpt (xanthine phosphoribosyltransferase), and ddl (D-alanine-D-alanine ligase).
‡New assigned sequence type.
