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Volume 15, Number 4—April 2009

Research

Novel Type of Streptococcus pneumoniae Causing Multidrug-Resistant Acute Otitis Media in Children

Qingfu Xu, Michael E. Pichichero, Janet R. Casey, and Mingtao ZengComments to Author 
Author affiliations: University of Rochester School of Medicine and Dentistry, Rochester, New York, USA (Q. Xu, M.E. Pichichero, M. Zeng); Legacy Pediatrics, Rochester (M.E. Pichichero, J.R. Casey)

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Table 1

Genotypic characteristics of Streptococcus pneumoniae serotype 19A strains with multiple antimicrobial drug resistance*

Strain Sequence type MIC, µg/mL
Allele no. of housekeeping genes†
Pen Cef Ery S.Tri aroE gdh gki recP spi xpt ddl
P270CR 320 2.0 1.0 >256 >32 4 16 19 15 6 20 1
060110 1451 4.0 1.0 >256 4.0 10 16 19 15 6 20 1
P270CL 320 2.0 1.0 >256 >32 4 16 19 15 6 20 1
Legacy strain 2722‡ 8.0 6.0 8.0 >32 7 11 10 15 6 8 1
P239CR 320 2.0 2.0 >256 8.0 4 16 19 5 6 20 1
0601034 320 2.0 1.0 >256 16.0 4 16 19 15 6 20 1
0601004V1NW 320 2.0 1.5 >256 6.0 4 16 19 15 6 20 1
0601004V1LMEF 320 3.0 1.5 >256 4.0 4 16 19 15 6 20 1

*Pen, benzylpenicillin; Cef, ceftriaxone; Ery, erythromycin; S.Tri, sulfamethoxazole-trimethoprim.
aroE (shikimate dehydrogenase), gdh (glucose-6-phosphate dehydrogenase), gki (glucose kinase), recP (transketolase), spi (signal peptidase I), xpt (xanthine phosphoribosyltransferase), and ddl (D-alanine-D-alanine ligase).
‡New assigned sequence type.

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