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Volume 15, Number 5—May 2009


CTX-M β-Lactamases in Escherichia coli from Community-acquired Urinary Tract Infections, Cambodia

Etienne RuppéComments to Author , Sopheak Hem, Sovannarith Lath, Valérie Gautier, Frédéric Ariey, Jean-Louis Sarthou, Didier Monchy, and Guillaume Arlet
Author affiliations: Institut Pasteur du Cambodge, Phnom Penh, Cambodia (E. Ruppé, S. Hem, S. Lath, F. Ariey, J.-L. Sarthou, D. Monchy); Université Pierre et Marie Curie-Paris Faculté de Médecine, Paris, France (V. Gautier, G. Arlet); Assistance Publique-Hôpitaux de Paris–Hôpital Tenon, Paris (V. Gautier, G. Arlet)

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Table 3

Mutations detected in the ampC promoter region of CTX-M β-lactam–resistant Escherichia coli*

Isolate CEF MIC, mg/L CTX-M Phylogenetic group Mutation at position†
−42 −32 −28 −18 −1 +22 +26 +27 +32 +58 +70 +81
E. coli K12 (U00096) C T G G C C T A G C C G
CEC1 16 Yes D T G T A T
CEC3 32 No D T G T A T
CEC4 32 No D A T T
CEC6 32 Yes D T G T A T
CEC8 32 Yes D T G T A T
CEC9 32 Yes D T G T A T
CEC10 32 Yes D T G T A T
CEC13 32 Yes D T G T A T
CEC14 16 Yes D T
CEC15 16 Yes D T
CEC19 32 No D T G T A T
CEC21 16 Yes D A T A
CEC22 16 Yes D T
CEC31 16 Yes D A T A
CEC57 32 No D A T G T A T
CEC88 32 No B2 A A
CEC89 32 Yes D T G T A T
CEC92 >128 Yes D T A T T
CEC93 >128 No D T G T A T

*CEF, cefoxitin; CEC, Cambodian E. coli.
†According to numbering of Jaurin and Grundström (30).

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