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Volume 15, Number 7—July 2009


Eczema Herpeticum and Clinical Criteria for Investigating Smallpox

David A. BoydComments to Author , Leonard C. Sperling, and Scott A. Norton
Author affiliations: Naval Hospital Jacksonville, Jacksonville, Florida, USA (D.A. Boyd); Uniformed Services University, Bethesda, Maryland, USA (L.C. Sperling, S.A. Norton)

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Major clinical criteria for smallpox*

Febrile prodrome Occurring 1–4 days before rash onset; fever >101ºF; and >1 of the following: prostration, headache, backache, chills, vomiting, or severe abdominal pain.
Classic smallpox lesions Deep-seated, firm/hard, round, well-circumscribed vesicles or pustules; as they evolve, lesions may become umbilicated or confluent.
Lesions in same stage of development On any single part of the body (e.g., face or arm); all lesions are in the same stage of development (i.e., all are vesicles or pustules).

*Source (3).

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