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Volume 15, Number 8—August 2009

Research

Transgenic Mice Expressing Porcine Prion Protein Resistant to Classical Scrapie but Susceptible to Sheep Bovine Spongiform Encephalopathy and Atypical Scrapie

Juan-Carlos Espinosa1, María-Eugenia Herva1, Olivier Andréoletti, Danielle Padilla, Caroline Lacroux, Hervé Cassard, Isabelle Lantier, Joaquin Castilla, and Juan-María TorresComments to Author 
Author affiliations: Centro de Investigación en Sanidad Animal, Madrid, Spain (J.-C. Espinosa, M.-E. Herva, D. Padilla, J. Castilla, J.-M. Torres); École Nationale Vétérinaire de Toulouse, Toulouse, France (O. Andréoletti, C. Lacroux, H. Cassard); Centre Institut National de la Recherche Agronomique de Tours, Nouzilly, France (I. Lantier)

Main Article

Figure 1

Electrophoretic profiles and antibody labeling of atypical proteinase K–resistant prion protein (PrPres) detected with monoclonal antibodies Sha31 (A) and 12B2 (B) in different isolates used for inoculating porcine PrP transgenic mice. Panels A and B were loaded with the same quantities of extracted PrPres from each sample. MW, molecular mass in kilodaltons.

Figure 1. Electrophoretic profiles and antibody labeling of atypical proteinase K–resistant prion protein (PrPres) detected with monoclonal antibodies Sha31 (A) and 12B2 (B) in different isolates used for inoculating porcine PrP transgenic mice. Panels A and B were loaded with the same quantities of extracted PrPres from each sample. MW, molecular mass in kilodaltons.

Main Article

1These authors contributed equally to this article.

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