Volume 15, Number 8—August 2009
Dispatch
Chronic Invasive Aspergillosis caused by Aspergillus viridinutans
Donald C. Vinh1, Yvonne R. Shea1, Pamela A. Jones, Alexandra F. Freeman, Adrian Zelazny, and Steven M. Holland
Table
Antifungal drug susceptibility results of Aspergillus viridinutans isolates relative to A. fumigatus reported at 48 hours*
| Isolate | Amphotericin B MIC, mg/L | Itraconazole MIC, mg/L | Voriconazole MIC, mg/L | Posaconazole MIC, mg/L | Caspofungin MEC, mg/L | Terbinafine MIC, mg/L |
|---|---|---|---|---|---|---|
| Patient 1 | 4 | 1 | 1 | 0.06 | 0.25 | ND |
| Patient 2† | 2–8 | 8 | 2–4 | <0.016–0.5 | 0.06–0.25 | 0.125–1 |
| A. fumigatus B-5233‡ | 0.5 | 0.5 | 0.5 | 0.125 | 0.25 | 2 |
*MEC, minimal effective concentration; ND, not determined.
†Composite results of 3 isolates from the patient.
‡Clinical isolate from patient with a fatal case of aspergillosis (courtesy of K.J. Kwon-Chung, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA).
