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Volume 15, Number 8—August 2009

Dispatch

Predictors of Death after Severe Streptococcus pyogenes Infection

Theresa L. LamagniComments to Author , Shona Neal, Catherine Keshishian, David Powell, Nicola Potz, Richard Pebody, Robert C. George, Georgia Duckworth, Jaana Vuopio-Varkila, and Androulla Efstratiou
Author affiliations: Health Protection Agency Centre for Infections, London, UK (T.L. Lamagni, S. Neal, C. Keshishian, D. Powell, N. Potz, R. Pebody, R. George, G. Duckworth, A. Efstratiou); National Public Health Institute, Helsinki, Finland (J. Vuopio-Varkila)

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Table

Conditions selected as cause of death within 7 days after diagnosis of severe Streptococcus pyogenes infection, England and Wales, 2003–2004

Condition classification (International Classification of Diseases, 10th Revision, code), N = 557* Underlying cause, no. (%) All mentions,† no. (%)
Infectious and parasitic diseases (A00–B99) 67 (12) 303 (54)
Neoplasms (C00–D48) 52 (9) 80 (14)
Diseases of the blood and blood forming organs and certain disorders involving the immune mechanism (D50–D89) 0 (0) 9 (2)
Endocrine system (E00–E90) 12 (2) 50 (9)
Mental and behavioral disorders (F00–F99) 19 (3) 32 (6)
Diseases of the nervous system (G00–G99) 7 (1) 12 (2)
Diseases of the eye and adnexa (H00–H59) 4 (1) 5 (1)
Diseases of the ear and mastoid process (H60–H95) 2 (<1) 2 (<1)
Diseases of the circulatory system (I00–I99) 108 (19) 297 (53)
Diseases of the respiratory system (J00–J99) 99 (18) 223 (40)
Diseases of the digestive system (K00–K93) 32 (6) 66 (12)
Diseases of the skin and subcutaneous tissue (L00–L99) 67 (12) 102 (18)
Diseases of the musculoskeletal system and connective tissue (M00–M99) 39 (7) 69 (12)
Diseases of the genitourinary system (N00–N99) 17 (3) 65 (12)
Complications of pregnancy, childbirth, and the puerperium (O00–O99) 1 (<1) 1 (<1)
Certain conditions originating in the perinatal period (P00–P96) 1 (<1) 3 (1)
Congenital abnormalities (Q00–Q99) 2 (<1) 7 (1)
Symptoms, signs, and abnormal clinical and laboratory findings not elsewhere classified (R00–R99) 7 (1) 49 (9)
Injury, poisoning, and certain other consequences of external causes (S00–T98) 0 (0) 49 (9)
External causes of mortality (V01–Y98) 21 (4) 61 (11)

*Percentages based on 557 deaths (cause of death was not available for 2 patients).
†Conditions noted on the death certificate as the underlying or contributory cause of death.

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