Worldwide Dissemination of the blaOXA-23 Carbapenemase Gene of Acinetobacter baumannii1
Pauline D. Mugnier, Laurent Poirel, Thierry Naas, and Patrice Nordmann
Author affiliations: Institut National de la Santé et de la Recherche Médicale Unité 914, Paris, France; Université Paris Sud, Bicêtre, France; 1This work was presented in part at the 19th European Congress of Clinical Microbiology and Infectious Diseases, Helsinki, Finland, May 16–19, 2009.
Figure 1. Genetic structures associated with the blaOXA-23 gene of Acinetobacter baumannii. A) Tn2006 from isolates 240, 512, 810, 859, 883 and AUS (ST22/ST2). B) Tn2008 from isolate 614. C) Tn2007 from isolates Ab14, BEL, and DOS. D) ISAba1 from isolates AS3, 1190, 861, and 877. Boundaries of Tn2006, Tn2007, and Tn2008 are indicated with the target site duplication likely generated by transposition events underlined. The 7-bp difference in the site of insertion of ISAba1 for isolate 614 is double-underlined. The open reading frame 1 (orf1), orf2, and orf3 genes of unknown function is indicated. tnpA, gene encoding a putative transposase; ATPase, gene encoding the putative AAA ATPase; DEAD, gene encoding the putative DEAD (Asp-Glu-Ala-Asp) helicase; DNAmethyl, DNA methylase.
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