Volume 16, Number 1—January 2010
Research
Worldwide Dissemination of the blaOXA-23 Carbapenemase Gene of Acinetobacter baumannii1
Pauline D. Mugnier, Laurent Poirel, Thierry Naas, and Patrice Nordmann
Table
Characteristics of 20 blaOXA-23-positive Acinetobacter baumannii clinical isolates*
| Isolate | Origin | Date of isolation | Specimen | EC | ST† | Copy no. of blaOXA-23 | Genetic location and size, kb | Genetic structure | MIC, μg/mL |
||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CAZ | IPM | MEM | |||||||||
| 240 | France | 2003 Dec | Tracheal aspirate | II | 22/2 | 1 | Chromosome, ≈200‡ | Tn2006 | 128 | >32 | >32 |
| 512 | Tahiti | 2004 Mar | Tracheal aspirate | II | 22/2 | 1 | Chromosome, ≈200‡ | Tn2006 | 64 | >32 | >32 |
| 761 | Vietnam | 2005 May | Bile | II | 22/2 | 1 | Chromosome, ≈200‡ | Tn2006 | 64 | >32 | >32 |
| 810 | New Caledonia | 2004 Jun | Blood | II | 22/2 | 1 | Chromosome, ≈200‡ | Tn2006 | 96 | >32 | >32 |
| 863 | Thailand | 2006 Jun | Urine | II | 22/2 | 1 | Chromosome, ≈200‡ | Tn2006 | 256 | >32 | >32 |
| 883 | Reunion | 2006 Jun | Unknown | II | 22/2 | 1 | Chromosome, ≈200‡ | Tn2006 | 128 | >32 | >32 |
| Ab13 | France | 2004 Jun | Urine | II | 22/2 | 2 | Chromosome, ≈200,‡ and plasmid, 70 | Tn2006 | 128 | >32 | >32 |
| AUS | Australia | 2004 Oct | Urine | II | 22/2 | 1 | Chromosome, ≈200‡ | Tn2006 | 96 | >32 | >32 |
| 859 | South Africa | 2006 Jan | Urine | II | 22/2 | 1 | Chromosome, ≈200‡ | Tn2006 | 128 | >32 | >32 |
| 585 | France | 2004 Jul | Tracheal aspirate | II | 53/2 | 1 | Chromosome, ≈200‡ | Tn2006 | 128 | >32 | >32 |
| 614 | Libya | 2004 Oct | Unknown | I | 25/20 | 1 | Plasmid, 130 | Tn2008 | 256 | >32 | 16 |
| AS3 | UAE† | 2006 Oct | Blood | I | 25/20 | 1 | Plasmid, 130 | ISAba1 | 256 | >32 | >32 |
| 1190 | Bahrain | 2008 Mar | Blood | I | 25/20 | 1 | Plasmid, 130 | ISAba1 | 256 | >32 | >32 |
| AS1 | UAE | 2006 Jul | Blood | I | 44/1 | 1 | Chromosome, ≈40‡ | Tn2006 | 256 | >32 | >32 |
| Ab14 | Algeria | 2004 Dec | Unknown | I | 44/1 | 2 | Plasmid, 25, and plasmid, >150 | Tn2007 | 4 | 16 | >32 |
| 910 | Reunion | 2006 Oct | Unknown | I | New1/1 | 1 | Plasmid, 130 | Tn2006 | 256 | 16 | 16 |
| 861 | Egypt | 2005 Nov | Sputum | I | New1/ 1 | 1 | Plasmid, 130 | ISAba1 | 8 | 32 | 32 |
| BEL | Belgium | 2007 Jul | Respiratory tract | I | New2/ 1 | 2 | Plasmid, 25, and plasmid, >150 | Tn2007 | 256 | >32 | >32 |
| DOS | France | 2004 May | Unknown | – | New3/ New | 2 | Plasmid, 25, and plasmid, >150 | Tn2007 | 8 | >32 | >32 |
| 877 | Brazil | 2006 Jul | Wound | – | New4/15 | 1 | Plasmid, 130 | ISAba1 | 96 | >32 | >32 |
*EC, European clone; ST, sequence type; UAE, United Arab Emirates; CAZ, ceftazidime; IPM, imipenem; MEM, meropenem. The MIC for ticarcillin was >256 μg/mL for all 20 isolates.
†ST determined by Bartual et al. (19) compared with ST determined by Nemec et al. (20).
‡Size of chromosome band carrying the blaOXA-23 gene, as determined by using the I-CeuI technique.
