Hepatitis E Virus Genotype Diversity in Eastern China
Wen Zhang , Yilin He, Hua Wang, Quan Shen, Li Cui, Xiaochun Wang, Shihe Shao, and Xiu G. Hua
Author affiliations: Author affiliations: Jiangsu University, Jiangsu, People’s Republic of China (W. Zhang, H. Wang, X. Wang, S. Shao); Taizhou Center for Disease Control and Prevention, Jiangsu (Y. He); Ohio State University, Wooster, Ohio, USA (Q. Shen); Shanghai JiaoTong University, Shanghai, People’s Republic of China (L. Cui, X. Hua)
Figure 1. Phylogenetic tree of hepatitis E virus isolates in eastern China, 2007–2009. The phylogenetic tree was produced with a 348-nt open reading frame 2 sequence alignment of 37 isolates from this study and other 31 reference sequences, using the neighbor-joining method and evaluated by using the interior branch test method with MEGA4 software (www.megasoftware.net). Percentage of bootstrap support is shown by values at the branch nodes of the tree. Only nodes with a bootstrap value >50 are labeled; these values are the result of resampling the data 1,000 times. Black diamonds, isolates identified in the current study; white squares, GenBank sequences with the highest sequence homology to our sequences; ?, genotype 4 strains that could not be subtyped but closely clustered with each other, forming a new subtype. Scale bar indicates nucleotide substitutions per position.
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