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Volume 16, Number 11—November 2010

Dispatch

Typing of Lymphogranuloma Venereum Chlamydia trachomatis Strains

Linus Christerson, Henry J.C. de Vries, Bertille de Barbeyrac, Charlotte A. Gaydos, Birgit Henrich, Steen Hoffmann, Julius Schachter, Johannes Thorvaldsen, Martí Vall-Mayans, Markus Klint, Björn HerrmannComments to Author , and Servaas A. Morré
Author affiliations: Uppsala University, Uppsala, Sweden (L. Christerson, M. Klint, B. Herrmann); Municipal Health Service Amsterdam, Amsterdam, the Netherlands (H.J.C. de Vries); University of Amsterdam, Amsterdam (H.J.C. de Vries); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (H.J.C. de Vries); Université Victor Segalen Bordeaux 2, Bordeaux, France (B. de Barbeyrac); Johns Hopkins University, Baltimore, Maryland, USA (C.A. Gaydos); Heinrich-Heine-University, Duesseldorf, Germany (B. Henrich); Statens Serum Institut, Copenhagen, Denmark (S. Hoffman); University of California, San Francisco, California, USA (J. Schachter); Oslo University Hospital, Oslo, Norway (J. Thorvaldsen); Catalan Health Institute, Barcelona, Spain (M. Vall-Mayans); VU University Medical Center, Amsterdam (S.A. Morré)

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Table

Genetic profiles of lymphogranuloma venereum specimens, Europe and United States*

Location Sample years No. specimens MLST profile
ompA
hctB CT058 CT144 CT172 pbpB
Europe† 2004–2009 49 27 13 17 13 29 28‡
Europe§ 2004–2009 1 27 13 17 13 29 39¶
USA# 2007–2009 5 27 13 17 13 29 28‡
USA** 1979–1985 3 27 13 17 13 29 28‡
USA** 1979–1985 6 44†† 13 17 13 29 28‡
USA** 1979–1985 7 18 13 23 13 29 40‡‡
USA** 1979–1985 5 18 13 19 6 28 22§§
USA** 1979–1985 1 18 37 19 6 28 22§§

*MLST, multilocus sequence typing; hctB, histone H1–like protein; pbpB, penicillin-binding protein; ompA, outer membrane protein A. Values are arbitrary designations referring to allele variants in our Chlamydia trachomatis MLST database (http://mlstdb.bmc.uu.se/). All MLST variants differ within regions with <5 point mutations unless otherwise indicated.
†Denmark (n = 7), France (n = 15), Germany (n = 1), the Netherlands (n = 9), Norway (n = 2), Spain (n = 6), and Sweden (n = 9).
ompA variant 28 is identical to the reference strain L2b/UCH-1/proctitis (AM884177.1).
§Spain.
ompA variant 39 contains a single point mutation compared with L2b/UCH-1/proctitis and has been deposited in GenBank under accession no. GQ413955.
#Baltimore, Maryland–Washington, DC.
**San Francisco, California.
††hctB variant 44 contains a novel 108-nt deletion and is unique in the MLST database.
‡‡ompA variant 40 contains 9 point mutations compared with reference strain L1/440 (DQ064294.1) and has been deposited in GenBank under accession no. GQ413956.
§§ompA variant 22 is identical to reference strain L2/434/Bu (AM884176.1).

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