Volume 16, Number 11—November 2010
Volume 16, Number 11—November 2010 PDF Version [PDF - 4.77 MB - 171 pages]
Oropharyngeal Cancer Epidemic and Human Papillomavirus
PDF Version [PDF - 307 KB - 7 pages]
T. Ramqvist and T. DalianisView Abstract
A growing body of research shows that human papillomavirus (HPV) is a common and increasing cause of oropharyngeal squamous cell carcinoma (OSCC). Thus, the International Agency for Research against Cancer has acknowledged HPV as a risk factor for OSCC, in addition to smoking and alcohol consumption. Recently, in Finland, the United Kingdom, the Netherlands, the United States, and Sweden, incidence of OSCC has increased, and an increase in the proportion of HPV-positive tumors was noted. On the basis of these data and reports indicating that patients with HPV-positive cancer have their first sexual experience at a young age and have multiple partners, we postulate that increased incidence of OSCC in the United States and some countries in northern Europe is because of a new, primarily sexually transmitted HPV epidemic. We also suggest that individualized treatment modalities and preventive vaccination should be further explored.
Regulatory Oversight and Safety of Probiotic Use
PDF Version [PDF - 161 KB - 5 pages]
V. Venugopalan et al.View Abstract
Depending on intended use of a probiotic (drug vs. dietary supplement), regulatory requirements differ greatly. For dietary supplements, premarketing demonstration of safety and efficacy and approval by the Food and Drug Administration are not required; only premarket notification is required. Saccharomyces boulardii is a probiotic regulated as a dietary supplement intended for use by the general healthy population, not as a drug to prevent, treat, or mitigate disease. However, since recent increases in incidence and severity of Clostridium difficile infection, probiotics have been used to treat recurrent and/or refractory disease in hospitalized patients. Saccharomyces fungemia secondary to use of the probiotic has been described for patients who are critically ill, are receiving nutrition enterally, or have a central venous catheter. Before use of a probiotic is considered for hospitalized patients, careful assessment of risk versus benefit must be made. To ensure patient safety, probiotics should be properly handled during administration.
Medscape CME Activity
Sulfadoxine/Pyrimethamine Intermittent Preventive Treatment for Malaria during Pregnancy PDF Version [PDF - 137 KB - 5 pages]P. Deloron et al.View SummaryView Abstract
Adequate methods for monitoring this treatment are needed.
For monitoring efficacy of sulfadoxine/pyrimethamine intermittent preventive treatment for malaria during pregnancy, data obtained from studies of children seemed inadequate. High prevalence of triple and quadruple mutants in the dihydropteroate synthase and dihydrofolate reductase genes of Plasmodium falciparum parasites contrasts with the efficacy of sulfadoxine/pyrimethamine in reducing low birthweights and placental infection rates. In light of this discrepancy, emphasis on using molecular markers for monitoring efficacy of intermittent preventive treatment during pregnancy appears questionable. The World Health Organization recently proposed conducting in vivo studies in pregnant women to evaluate molecular markers for detecting resistance precociously. Other possible alternative strategies are considered.
Decreasing Shigellosis-related Deaths without Shigella spp.–specific Interventions, Asia
PDF Version [PDF - 158 KB - 6 pages]
P. Bardhan et al.View Abstract
In 1999, a review of the literature for 1966–1997 suggested that ≈1.1 million persons die annually of shigellosis, including ≈880,000 in Asia. Our recent review of the literature for 1990–2009 indicates that ≈125 million shigellosis cases occur annually in Asia, of which ≈14,000 are fatal. This estimate for illnesses is similar to the earlier estimate, but the number of deaths is 98% lower; that is, the lower estimate of deaths is associated with markedly reduced case-fatality rates rather than fewer cases. Shigella spp.–related deaths decreased substantially during a period without Shigella spp.–specific interventions. We speculate that nonspecific interventions, e.g., measles vaccination, vitamin A supplementation, and improved nutrition, may have led to the reduced number of shigellosis-related deaths.
Salmonella enterica Pulsed-Field Gel Electrophoresis Clusters, Minnesota, USA, 2001–2007
PDF Version [PDF - 289 KB - 8 pages]
J. M. Rounds et al.View Abstract
We determined characteristics of Salmonella enterica pulsed-field gel electrophoresis clusters that predict their being solved (i.e., that result in identification of a confirmed outbreak). Clusters were investigated by the Minnesota Department of Health by using a dynamic iterative model. During 2001–2007, a total of 43 (12.5%) of 344 clusters were solved. Clusters of >4 isolates were more likely to be solved than clusters of 2 isolates. Clusters in which the first 3 case isolates were received at the Minnesota Department of Health within 7 days were more likely to be solved than were clusters in which the first 3 case isolates were received over a period >14 days. If resources do not permit investigation of all S. enterica pulsed-field gel electrophoresis clusters, investigation of clusters of >4 cases and clusters in which the first 3 case isolates were received at a public health laboratory within 7 days may improve outbreak investigations.
Outbreaks of Pandemic (H1N1) 2009 and Seasonal Influenza A (H3N2) on Cruise Ship
PDF Version [PDF - 232 KB - 7 pages]
K. A. Ward et al.View Abstract
To determine the extent and pattern of influenza transmission and effectiveness of containment measures, we investigated dual outbreaks of pandemic (H1N1) 2009 and influenza A (H3N2) that had occurred on a cruise ship in May 2009. Of 1,970 passengers and 734 crew members, 82 (3.0%) were infected with pandemic (H1N1) 2009 virus, 98 (3.6%) with influenza A (H3N2) virus, and 2 (0.1%) with both. Among 45 children who visited the ship’s childcare center, infection rate for pandemic (H1N1) 2009 was higher than that for influenza A (H3N2) viruses. Disembarked passengers reported a high level of compliance with isolation and quarantine recommendations. We found 4 subsequent cases epidemiologically linked to passengers but no evidence of sustained transmission to the community or passengers on the next cruise. Among this population of generally healthy passengers, children seemed more susceptible to pandemic (H1N1) 2009 than to influenza (H3N2) viruses. Intensive disease control measures successfully contained these outbreaks.
Lymphotropism of Merkel Cell Polyomavirus Infection, Nova Scotia, Canada
PDF Version [PDF - 359 KB - 8 pages]
S. Toracchio et al.View Abstract
To test the hypothesis that Merkel cell polyomavirus (MCPyV) can infect cells of the lymphoid system, we analyzed 353 specimens, including 152 non-Hodgkin lymphomas, 44 Hodgkin lymphomas, 110 benign lymph nodes, 27 lymph nodes with metastasis, and 20 extranodal tissue samples. MCPyV DNA was detected by quantitative PCR in 13 (6.6%) of 196 lymphomas, including 5 (20.8%) of 24 chronic lymphocytic leukemia specimens, and in 11 (10%) of 110 benign lymph nodes, including 8 (13.1%) of 61 samples of reactive hyperplasia and 3 (10.3%) of 29 normal lymph nodes. Other samples were MCPyV negative. Sequence analysis of 9 virus-positive samples confirmed the identity of MCPyV; 3 viral strains were represented. Immunohistochemical testing showed that 1 T-cell lymphoma expressed MCPyV T-antigen. These findings suggest that the lymphoid system plays a role in MCPyV infection and may be a site for MCPyV persistence.
Genetic Structure of Plasmodium falciparum and Elimination of Malaria, Comoros Archipelago
PDF Version [PDF - 206 KB - 9 pages]
S. Rebaudet et al.View Abstract
The efficacy of malaria control and elimination on islands may depend on the intensity of new parasite inflow. On the Comoros archipelago, where falciparum malaria remains a major public health problem because of spread of drug resistance and insufficient malaria control, recent interventions for malaria elimination were planned on Moheli, 1 of 4 islands in the Comoros archipelago. To assess the relevance of such a local strategy, we performed a population genetics analysis by using multilocus microsatellite and resistance genotyping of Plasmodium falciparum sampled from each island of the archipelago. We found a contrasted population genetic structure explained by geographic isolation, human migration, malaria transmission, and drug selective pressure. Our findings suggest that malaria elimination interventions should be implemented simultaneously on the entire archipelago rather than restricted to 1 island and demonstrate the necessity for specific chemoresistance surveillance on each of the 4 Comorian islands.
Comparison of 3 Infrared Thermal Detection Systems and Self-Report for Mass Fever Screening
PDF Version [PDF - 302 KB - 8 pages]
A. V. Nguyen et al.View Abstract
Despite limited evidence regarding their utility, infrared thermal detection systems (ITDS) are increasingly being used for mass fever detection. We compared temperature measurements for 3 ITDS (FLIR ThermoVision A20M [FLIR Systems Inc., Boston, MA, USA], OptoTherm Thermoscreen [OptoTherm Thermal Imaging Systems and Infrared Cameras Inc., Sewickley, PA, USA], and Wahl Fever Alert Imager HSI2000S [Wahl Instruments Inc., Asheville, NC, USA]) with oral temperatures (>100°F = confirmed fever) and self-reported fever. Of 2,873 patients enrolled, 476 (16.6%) reported a fever, and 64 (2.2%) had a confirmed fever. Self-reported fever had a sensitivity of 75.0%, specificity 84.7%, and positive predictive value 10.1%. At optimal cutoff values for detecting fever, temperature measurements by OptoTherm and FLIR had greater sensitivity (91.0% and 90.0%, respectively) and specificity (86.0% and 80.0%, respectively) than did self-reports. Correlations between ITDS and oral temperatures were similar for OptoTherm (ρ = 0.43) and FLIR (ρ = 0.42) but significantly lower for Wahl (ρ = 0.14; p<0.001). When compared with oral temperatures, 2 systems (OptoTherm and FLIR) were reasonably accurate for detecting fever and predicted fever better than self-reports.
Measles Virus Strain Diversity, Nigeria and Democratic Republic of the Congo
PDF Version [PDF - 300 KB - 7 pages]
J. R. Kremer et al.View Abstract
We investigated the genetic diversity of measles virus (MV) in Nigeria (2004–2005) and the Democratic Republic of the Congo (DRC) (2002–2006). Genotype B3 strains circulating in Kinshasa, DRC, in 2002–2003 were fully replaced by genotype B2 in 2004 at the end of the second Congo war. In Nigeria (2004–2005), two genetic clusters of genotype B3, both of which were most closely related to 1 variant from 1998, were identified. Longitudinal analysis of MV strain diversity in Nigeria suggested that only a few of the previously described 1997–1998 variants had continued to circulate, but this finding was concomitant with a rapid restoration of genetic diversity, probably caused by low vaccination coverage and high birth rates. In contrast, the relatively low genetic diversity of MV in DRC and the genotype replacement in Kinshasa reflect a notable improvement in local measles control.
Effect of Vaccination on Bordetella pertussis Strains, China
PDF Version [PDF - 335 KB - 7 pages]
L. Zhang et al.View Abstract
Whole-cell pertussis vaccine was introduced in China in the early 1960s. We used standard typing methods to compare 96 Bordetella pertussis isolates collected before and after introduction of vaccination, during 1953–2005. The following vaccine-type alleles of the pertussis toxin (ptx) gene were characteristic for all prevaccination strains: ptxA2, ptxA3, and ptxA4. The shift to ptxA1 occurred since 1963. All isolates collected since 1983 contained ptxA1. Pertactin (prn) allele 1, prn1, was predominant, although prn2 and prn3 have been detected since 2000. Serotypes fimbriae (Fim) 2 and Fim2,3 were found in all isolates collected before 1986. During 1997–2005, Fim3 became prevalent. Although changes in electrophoresis profiles over time were observed, the predominant profiles during 1997–2005 resembled those during the prevaccine era and those found in Europe before the 1990s. B. pertussis strains in China may differ from those in countries that have a long history of high vaccine coverage.
Medscape CME Activity
Enhanced Surveillance of Coccidioidomycosis, Arizona, USA, 2007–2008 PDF Version [PDF - 187 KB - 8 pages]C. A. Tsang et al.View SummaryView Abstract
Additional public and provider education are needed to reduce delays in diagnosis.
Coccidioidomycosis is endemic to the southwestern United States; 60% of nationally reported cases occur in Arizona. Although the Council of State and Territorial Epidemiologists case definition for coccidioidomycosis requires laboratory and clinical criteria, Arizona uses only laboratory criteria. To validate this case definition and characterize the effects of coccidioidomycosis in Arizona, we interviewed every tenth case-patient with coccidioidomycosis reported during January 2007–February 2008. Of 493 patients interviewed, 44% visited the emergency department, and 41% were hospitalized. Symptoms lasted a median of 120 days. Persons aware of coccidioidomycosis before seeking healthcare were more likely to receive an earlier diagnosis than those unaware of the disease (p = 0.04) and to request testing for Coccidioides spp. (p = 0.05). These findings warrant greater public and provider education. Ninety-five percent of patients interviewed met the Council of State and Territorial Epidemiologists clinical case definition, validating the Arizona laboratory-based case definition for surveillance in a coccidiodomycosis-endemic area.
Hepatitis E Virus Infection in Sheltered Homeless Persons, France
PDF Version [PDF - 435 KB - 3 pages]
M. Kaba et al.View Abstract
To determine the prevalence of hepatitis E virus (HEV) infection among sheltered homeless persons in Marseille, France, we retrospectively tested 490 such persons. A total of 11.6% had immunoglobulin (Ig) G and 2.5% had IgM against HEV; 1 person had HEV genotype 3f. Injection drug use was associated with IgG against HEV.
Multidrug-Resistant Salmonella enterica Serovar Infantis, Israel
PDF Version [PDF - 615 KB - 4 pages]
O. Gal-Mor et al.View Abstract
To determine whether rapid emergence of Salmonella enterica serovar Infantis in Israel resulted from an increase in different biotypes or spread of 1 clone, we characterized 87 serovar Infantis isolates on the genotypic and phenotypic levels. The emerging strain comprised 1 genetic clone with a distinct pulsed-field gel electrophoresis profile and a common antimicrobial drug resistance pattern.
Enterovirus 71 Infection with Central Nervous System Involvement, South Korea
PDF Version [PDF - 384 KB - 3 pages]
W. Ryu et al.View Abstract
We assessed neurologic sequelae associated with an enterovirus 71 (EV71) outbreak in South Korea during 2009. Four of 94 patients had high signal intensities at brainstem or cerebellum on magnetic resonance imaging. Two patients died of cardiopulmonary collapse; 2 had severe neurologic sequelae. Severity and case-fatality rates may differ by EV71 genotype or subgenotype.
Estimates of the True Number of Cases of Pandemic (H1N1) 2009, Beijing, China
PDF Version [PDF - 373 KB - 3 pages]
X. Wang et al.View Abstract
During 2009, a total of 10,844 laboratory-confirmed cases of pandemic (H1N1) 2009 were reported in Beijing, People’s Republic of China. However, because most cases were not confirmed through laboratory testing, the true number is unknown. Using a multiplier model, we estimated that ≈1.46–2.30 million pandemic (H1N1) 2009 infections occurred.
Reassortment of Ancient Neuraminidase and Recent Hemagglutinin in Pandemic (H1N1) 2009 Virus
PDF Version [PDF - 376 KB - 3 pages]
P. Bhoumik and A. L. HughesView Abstract
Sequence analyses show that the outbreak of pandemic (H1N1) 2009 resulted from the spread of a recently derived hemagglutinin through a population of ancient and more diverse neuraminidase segments. This pattern implies reassortment and suggests that the novel form of hemagglutinin conferred a selective advantage.
Extended Spectrum β-Lactamase–producing Escherichia coli in Neonatal Care Unit
PDF Version [PDF - 448 KB - 3 pages]
S. Tschudin-Sutter et al.View Abstract
An outbreak of extended-spectrum β-lactamase–producing Escherichia coli in a neonatal care unit began with transmission from a mother to her newborn twins during vaginal delivery. Subsequently, infection spread by healthcare worker contact with other neonates; a healthcare worker also was infected. Knowledge about transmission may improve infection control measures.
Typing of Lymphogranuloma Venereum Chlamydia trachomatis Strains
PDF Version [PDF - 371 KB - 3 pages]
L. Christerson et al.View Abstract
We analyzed by multilocus sequence typing 77 lymphogranuloma venereum Chlamydia trachomatis strains from men who have sex with men in Europe and the United States. Specimens from an outbreak in 2003 in Europe were monoclonal. In contrast, several strains were in the United States in the 1980s, including a variant from Europe.
Plasmid-mediated Quinolone Resistance among Non-TyphiSalmonella enterica Isolates, USA
PDF Version [PDF - 411 KB - 3 pages]
M. Sjölund-Karlsson et al.View Abstract
We determined the prevalence of plasmid-mediated quinolone resistance mechanisms among non-Typhi Salmonella spp. isolated from humans, food animals, and retail meat in the United States in 2007. Six isolates collected from humans harbored aac(6′)Ib-cr or a qnr gene. Most prevalent was qnrS1. No animal or retail meat isolates harbored a plasmid-mediated mechanism.
Genome Sequence Conservation of Hendra Virus Isolates during Spillover to Horses, Australia
PDF Version [PDF - 406 KB - 3 pages]
G. A. Marsh et al.View Abstract
Bat-to-horse transmission of Hendra virus has occurred at least 14 times. Although clinical signs in horses have differed, genome sequencing has demonstrated little variation among the isolates. Our sequencing of 5 isolates from recent Hendra virus outbreaks in horses found no correlation between sequences and time or geographic location of outbreaks.
Comparison of Survey Methods in Norovirus Outbreak Investigation, Oregon, USA, 2009
PDF Version [PDF - 722 KB - 4 pages]
J. Y. Oh et al.View Abstract
We compared data from an Internet-based survey and a telephone-based survey during a 2009 norovirus outbreak in Oregon. Survey initiation, timeliness of response, and attack rates were comparable, but participants were less likely to complete Internet questions. Internet-based surveys permit efficient data collection but should be designed to maximize complete responses.
Enterovirus 75 Encephalitis in Children, Southern India
PDF Version [PDF - 341 KB - 3 pages]
P. Lewthwaite et al.View Abstract
Recent outbreaks of enterovirus in Southeast Asia emphasize difficulties in diagnosis of this infection. To address this issue, we report 5 (4.7%) children infected with enterovirus 75 among 106 children with acute encephalitis syndrome during 2005–2007 in southern India. Throat swab specimens may be useful for diagnosis of enterovirus 75 infection.
Isolation of Ancestral Sylvatic Dengue Virus Type 1, Malaysia
PDF Version [PDF - 384 KB - 3 pages]
B. Teoh et al.View Abstract
Ancestral sylvatic dengue virus type 1, which was isolated from a monkey in 1972, was isolated from a patient with dengue fever in Malaysia. The virus is neutralized by serum of patients with endemic DENV-1 infection. Rare isolation of this virus suggests a limited spillover infection from an otherwise restricted sylvatic cycle.
Experimental Pandemic (H1N1) 2009 Virus Infection of Cats
PDF Version [PDF - 401 KB - 3 pages]
J. M. van den Brand et al.View Abstract
To demonstrate that pandemic (H1N1) 2009 virus may cause respiratory disease in cats, we intratracheally infected cats. Diffuse alveolar damage developed. Seroconversion of sentinel cats indicated cat-to-cat virus transmission. Unlike in cats infected with highly pathogenic avian influenza virus (H5N1), extrarespiratory lesions did not develop in cats infected with pandemic (H1N1) 2009 virus.
Prevalence and Genetic Structures of Streptococcus pneumoniae Serotype 6D, South Korea
PDF Version [PDF - 456 KB - 3 pages]
E. H. Choi et al.View Abstract
To determine prevalence and genetic structures of new serotype 6D strains of pneumococci, we examined isolates from diverse clinical specimens in South Korea during 1991–2008. Fourteen serotype 6D strains accounted for 10.4% of serogroup 6 pneumococci from blood, sputum, nasopharynx, and throat samples. Serotype 6D strains consisted of 3 sequence types.
Importation of Dengue Virus Type 3 to Japan from Tanzania and Côte d’Ivoire
PDF Version [PDF - 417 KB - 3 pages]
M. Moi et al.View Abstract
Travelers can introduce viruses from disease-endemic to non–disease-endemic areas. Serologic and virologic tests confirmed dengue virus infections in 3 travelers returning to Japan: 2 from Tanzania and 1 from Côte d’Ivoire. Phylogenetic analysis of the envelope gene showed that 2 genetically related virus isolates belonged to dengue virus type 3 genotype III.
Hemolytic–Uremic Syndrome in a Grandmother
PDF Version [PDF - 356 KB - 4 pages]
L. C. Crawford et al.
Fatal Avian Influenza (H5N1) Infection in Human, China
PDF Version [PDF - 93 KB - 3 pages]
J. Zhang et al.
Mycobacterium heckeshornense Infection in HIV-infected Patient
PDF Version [PDF - 88 KB - 3 pages]
R. A. Ahmed et al.
Typhoid Fever among Children, Ghana
PDF Version [PDF - 96 KB - 2 pages]
F. Marks et al.
Geographic Expansion of Baylisascaris procyonis Roundworms, Florida, USA
PDF Version [PDF - 82 KB - 2 pages]
E. L. Blizzard et al.
Vibrio cholerae O1 Variant with Reduced Susceptibility to Ciprofloxacin, Western Africa
PDF Version [PDF - 88 KB - 2 pages]
M. Quilici et al.
Yersinia pestis DNA Sequences in Late Medieval Skeletal Finds, Bavaria
PDF Version [PDF - 93 KB - 2 pages]
I. Wiechmann et al.
Acute Encephalopathy and Pandemic (H1N1) 2009
PDF Version [PDF - 121 KB - 3 pages]
S. M. Moon et al.
Oseltamivir-Resistant Pandemic (H1N1) 2009 Treated with Nebulized Zanamivir
PDF Version [PDF - 115 KB - 3 pages]
L. Da Dalt et al.
Two Clusters of HIV-1 Infection, Rural Idaho, USA, 2008
PDF Version [PDF - 81 KB - 2 pages]
R. J. Nett et al.
Enteric Viruses in Ready-to-Eat Packaged Leafy Greens
PDF Version [PDF - 150 KB - 3 pages]
K. Mattison et al.
Shigella spp. Antimicrobial Drug Resistance, Papua New Guinea, 2000–2009
PDF Version [PDF - 100 KB - 3 pages]
A. Rosewell et al.
Pandemic (H1N1) 2009 and Oseltamivir Resistance in Hematology/Oncology Patients
PDF Version [PDF - 96 KB - 3 pages]
C. Wolfe et al.
The Persistence of Influenza Infection
PDF Version [PDF - 76 KB - 3 pages]
J. W. Tang
Books and Media
Smallpox Zero: An Illustrated History of Smallpox and Its Eradication
PDF Version [PDF - 111 KB - 1 page]
P. L. Stockton
About the Cover
Peer Reviewed Report Available Online OnlyInternational Conference on Emerging Infectious Diseases, 2010 PDF Version [PDF - 21 KB - 3 pages]N. Marano et al.
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