Emerging Infectious Disease ISSN: 1080-6059

Characterization of Nipah Virus from Naturally Infected Pteropus vampyrus Bats, Malaysia

Sohayati A. Rahman

, Sharifah S. Hassan, Kevin J. Olival, Maizan Mohamed, Li-Yen Chang, Latiffah Hassan, Norsharina M. Saad, Syamsiah A. Shohaimi, Zaini C. Mamat, M.S. Naim, Jonathan H. Epstein, Arshad S. Suri, Hume E. Field, Peter Daszak, and the Henipavirus Ecology Research Group

Author affiliations: Author affiliations: Veterinary Research Institute, Ipoh, Malaysia (S.A. Rahman, S.A. Shohaimi, Z.C. Mamat, M.S. Naim); Monash University, Selangor, Malaysia (S.S. Hassan); EcoHealth Alliance, New York, New York, USA (K.J. Olival, J.H. Epstein, P. Daszak); University of Science Malaysia, Kelantan, Malaysia (M. Mohamed); University of Malaya, Kuala Lumpur, Malaysia (L.-Y. Chang); University Putra Malaysia, Serdang, Selangor (L. Hassan, A.S. Suri); Ministry of Science, Technology and Innovation, Putrajaya, Malaysia (N.M. Saad); Queensland Primary Industries and Fisheries, Moorooka, Queensland, Australia (H.E. Field)

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Figure 2

Partial nucleocapsid gene (358 bp) maximum-likelihood tree for all available Nipah virus (NiV) sequences (seqs) in GenBank, showing a high level of NiV sequence diversity in Pteropus lylei bat isolates from Thailand. NiV P. vampyrus (box) is most closely related to AY858110 from P. lylei bats and forms a large clade that includes other P. lylei bat isolates and all NiV sequences from Malaysia. GenBank accession numbers are given for NiV isolates from pigs in Malaysia (AJ627196, Tambun; AJ564621

Figure 2. Partial nucleocapsid gene (358 bp) maximum-likelihood tree for all available Nipah virus (NiV) sequences (seqs) in GenBank, showing a high level of NiV sequence diversity in Pteropus lylei bat isolates from Thailand. NiV P. vampyrus (box) is most closely related to AY858110 from P. lylei bats and forms a large clade that includes other P. lylei bat isolates and all NiV sequences from Malaysia. GenBank accession numbers are given for NiV isolates from pigs in Malaysia (AJ627196, Tambun; AJ564621, Sg. Buloh; and AJ564622, Seremban), humans in Malaysia (AJ564623, AF212302, AY029767, and AY029768), humans in Bangladesh (AY988601), P. hypomelanus bats in Malaysia (AF376747), P. lylei bats in Cambodia (nucleocapsid gene-AY858110, DQ061851–58, EF070182–90, EU603724–58, EU620498, and EU624735–37), and Hendra virus from Australia (AF017149). Scale bar indicates nucleotide substitutions per site.

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¹Members of the Henipavirus Ecology Research Group are listed on the group’s website (www.henipavirus.org/staff/Staff.htm).

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