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Volume 16, Number 12—December 2010
Dispatch

Characterization of Nipah Virus from Naturally Infected Pteropus vampyrus Bats, Malaysia

Sohayati A. RahmanComments to Author , Sharifah S. Hassan, Kevin J. Olival, Maizan Mohamed, Li-Yen Chang, Latiffah Hassan, Norsharina M. Saad, Syamsiah A. Shohaimi, Zaini C. Mamat, M.S. Naim, Jonathan H. Epstein, Arshad S. Suri, Hume E. Field, Peter Daszak, and the Henipavirus Ecology Research Group
Author affiliations: Author affiliations: Veterinary Research Institute, Ipoh, Malaysia (S.A. Rahman, S.A. Shohaimi, Z.C. Mamat, M.S. Naim); Monash University, Selangor, Malaysia (S.S. Hassan); EcoHealth Alliance, New York, New York, USA (K.J. Olival, J.H. Epstein, P. Daszak); University of Science Malaysia, Kelantan, Malaysia (M. Mohamed); University of Malaya, Kuala Lumpur, Malaysia (L.-Y. Chang); University Putra Malaysia, Serdang, Selangor (L. Hassan, A.S. Suri); Ministry of Science, Technology and Innovation, Putrajaya, Malaysia (N.M. Saad); Queensland Primary Industries and Fisheries, Moorooka, Queensland, Australia (H.E. Field)

Main Article

Table 2

Summary of deduced amino acid changes in the N, P, M, F, G, and L proteins of NiV from Pteropus vampyrus bats compared with other NiV isolates*

Isolate†
N, aa position
P, aa position
NiV isolate 429 432 457 41 140 195 295 304 309 408 410
P. vampyrus V E D R A P S A T G T
Human-CDC I G N Q T L N T A T A
P. hypomelanus I G N Q T L N T A T A
Pig-Tambun I
G
N

Q
T
L
N
A
A
T
A
P, aa position
NiV isolate 412 419 420 425 427 430 437 438 439 440 454
P. vampyrus N K M R G P P P Q S P
Human-CDC Y N V S A H Y Q E G T
P. hypomelanus Y N V S A H Y Q E G T
Pig-Tambun Y
N
V
S
A
H
Y
Q
E
G
T
P, aa position
M, aa position
F, aa position
NiV isolate 463 464 467 468 471 664 147 234 331 11 63
P. vampyrus K I P H N V G Y V S A
Human-CDC E V V D D I S S I C P
P. hypomelanus E V V D D I S S I C P
Pig-Tambun E
V
V
D
D
I

G
S
I

C
P
F, aa position
G, aa position
L, aa position
NiV isolate 460 20 186 426 444 470 481 223 1645 1753 2039
P. vampyrus K N D I V Q D N F V N
Human-CDC I I N V I L N T S M H
P. hypomelanus I I N V I L N T F M H
Pig-Tambun I N N V I L N N F V N

*N, nucleocapsid; P, phosphoprotein; M, matrix; F, fusion, G, attachment; L, polymerase; NiV, Nipah virus; CDC, Centers for Disease Control and Prevention. Boldface indicates amino acid changes.
†GenBank accession nos.: NiV Human-CDC , AF212302; NiV P. hypomelanus, AF376747; NiV Pig-Tambun, AJ627196.

Main Article

1Members of the Henipavirus Ecology Research Group are listed on the group’s website (www.henipavirus.org/staff/Staff.htm).

Page created: August 28, 2011
Page updated: August 28, 2011
Page reviewed: August 28, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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