Associations between Mycobacterium tuberculosis Strains and Phenotypes
Figure 2. Maximum-parsimony tree constructed based on 3 independent sets of markers: large sequence polymorphisms (LSPs), single nucleotide polymorphisms (SNPs), and number of repeats in the locus 24 using the following assumptions: 1) SNPs are irreversible unique events; 2) LSPs are irreversible rare events; 3) spoligotypes are not produced by convergent events; and 4) variable number tandem repeat (VNTR) loci can both acquire and lose repeats. EAI, East African–Indian; MIRU, mycobacterial interspersed repetitive unit code; EuroAm, European American; CAS, Central Asian; MBOV, M. bovis; MAFR, M. africanum; BCG, bacillus Calmette-Guérin. The X, T, LAM, S, and Haarlem families are European American types.