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Volume 16, Number 2—February 2010

Research

Associations between Mycobacterium tuberculosis Strains and Phenotypes

Timothy Brown1, Vladyslav Nikolayevskyy1, Preya Velji, and Francis DrobniewskiComments to Author 
Author affiliations: United Kingdom Health Protection Agency, London UK (T. Brown, F. Drobniewski); Queen Mary College, University of London, London (V. Nikolayevskyy, P. Velji, F. Drobniewski); 1These authors contributed equally to this article.

Main Article

Table 1

Analysis of associations between Mycobacterium tuberculosis phylogenetic lineages defined by SNP analysis and spoligotyping families in the group of isolates not classified using VNTR codes, UK*

Spoligotypes Lineages (6,7) and relevant MIRU codes (12)
M. tuberculosis
M. bovis; 10–2, 40–2, C–5
I/East Asian; 
39–3, A–4, C–4 II/European American; 
16–1,2,3, 39–2, B–1,2 III/EAI; 
23–5, C–2 IV/Indo-Oceanic; 
24–2, 26–2
H37Rv, n = 2 0 2 0 0 0
Beijing, n = 13 13 0 0 0 0
LAM, n = 17 0 17 0 0 0
T, n = 53 1
600740007764671† 51 0 1
777200007403371† 0
Haarlem, n = 21 0 20 0 1
777777774000731† 0
EAI, n = 61 2
777777770003331†
477777377413771† 1
777734000000031† 0 58 0
CAS, n = 18 0 0 18 0 0
X, n = 9 0 9 0 0 0
S, n = 2 0 2 0 0 0
Family 33, n = 4 1 1 0 2 0
Family 35, n = 7 7 0 0 0 0
Family 36, n = 5 0 5 0 0 0
M. bovis BCG, n = 4 0 0 0 0 4
M. africanum, n = 35 34 1
710044706302261* 0 0 0

*SNP, single nucleotide polymorphism; VNTR, variable number tandem repeat; MIRU, mycobacterial interspersed repetitive unit; EAI, East African–Indian; LAM Latin American; CAS, Central Asian; BCG, bacillus Calmette-Guérin. European American includes the X, T, LAM, S, and Haarlem families.
†Octal codes indicate spoligotyping patterns for isolates with disagreements between SNP- and spoligotype-defined lineages. Dominant families within each lineage are in boldface.

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