Serologic Markers for Detecting Malaria in Areas of Low Endemicity, Somalia, 2008
Teun Bousema , Randa M. Youssef, Jackie Cook, Jonathan Cox, Victor A. Alegana, Jamal Amran, Abdisalan M. Noor, Robert W. Snow, and Chris Drakeley
Author affiliations: London School of Hygiene and Tropical Medicine, London, UK (T. Bousema, J. Cook, J. Cox, C. Drakeley); University of Alexandria, Alexandria, Egypt (R.M. Youssef); Kenya Medical Research Institute–Wellcome Trust Research Programme, Nairobi, Kenya (R.M. Youssef, V.A. Alegana, J. Amran, A.M. Noor, R.W. Snow); Roll Back Malaria–World Health Organization, Hargeisa, Somalia (J. Amran); University of Oxford, Oxford, UK (A.M. Noor, R.W. Snow)
Figure 2. Age-adjusted optical density (OD) values for antibodies against Plasmodium falciparum in the study population, Ceel-Bardaale, Somalia, 2008. Colored dots indicate mean age-adjusted optical densities per household for combined seroreactivity to P. falciparum merozoite surface protein 119 and apical membrane antigen 1. The large circle indicates a statistically significant cluster of higher P. falciparum seroreactivity that was detected by a spatial scan on the age-adjusted seroreactivity of individual study participants to both P. falciparum antigens (p = 0.002). As a result of age adjustment, some persons had lower than expected seroreactivities. This adjustment resulted in negative OD values.
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