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Volume 16, Number 3—March 2010

Research

Chikungunya Virus Infection during Pregnancy, Réunion, France, 2006

Xavier FritelComments to Author , Olivier Rollot, Patrick Gérardin, Bernard-Alex Gaüzère, Jacques Bideault, Louis Lagarde, Barbara Dhuime, Eric Orvain, Fabrice Cuillier, Duksha Ramful, Sylvain Sampériz, Marie-Christine Jaffar-Bandjee, Alain Michault, Liliane Cotte, Monique Kaminski, Alain Fourmaintraux, and the Chikungunya-Mère-Enfant Team
Author affiliations: Centre Hospitalier Régional de la Réunion, Saint-Denis, France (X. Fritel, P. Gérardin, B.-A. Gaüzère, E. Orvain, F. Cuillier, D. Ramful, S. Sampériz, M.-C. Jaffar-Bandjee, A. Michault, L. Cotte, A. Fourmaintraux); Centre d’Investigation Clinique–Epidémiologie Clinique de la Réunion, Saint-Denis (O. Rollot, P. Gérardin); Institut National de la Santé et de la Recherche Médicale, Villejuif, France (X. Fritel, P. Gérardin, M. Kaminski); Centre Hospitalier Intercommunal de Saint-Benoit-Saint-André, Saint-Benoit, France (J. Bideault); Centre Hospitalier Gabriel-Martin, Saint-Paul, France (L. Lagarde); Clinique Sainte-Clotilde, Saint-Denis (B. Dhuime); Université Pierre et Marie Curie 6, Paris, France (X. Fritel, P. Gérardin, M. Kaminski)

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Table 3

Pregnancy outcome according to chikungunya virus infection during pregnancy, Réunion, France, 2006*

Characteristic Infected,† 
no. (%), n = 658 Not infected,‡ no. (%), n = 655 p value Unadjusted OR (95% CI) Adjusted OR (95% CI)
Hospital admission during pregnancy
Yes 266 (40.4) 191 (29.2) 1.65 (1.31–2.07) 1.52 (1.18–1.95)
No
392 (59.6)
464 (70.8)
<0.0001
1
1
Hospital admission during pregnancy, suspected infection with chikungunya virus excluded
Yes 180 (28.0) 136 (26.1) 0.91 (0.70–1.18) 0.83 (0.62–1.10)
No
464 (72.0)
385 (73.9)
0.48
1
1
Vaginal bleeding during pregnancy
Yes 55 (8.4) 68 (10.4) 0.79 (0.55–1.15) 0.94 (0.63–1.42)
No
596 (91.6)
584 (89.6)
0.22
1
1
Obstetric hemorrhaging
Yes 36 (5.6) 42 (6.5) 0.85 (0.54–1.35) 0.87 (0.53–1.42)
No
609 (94.4)
605 (93.5)
0.49
1
1
Mode of delivery§
Vaginal 545 (83.8) 530 (81.5) 0.27 1 1
Cesarean
105 (16.2)
120 (18.5)

0.85 (0.64–1.14)
0.77 (0.56–1.06)
Mean gestational age, wk§ 39.0 (2.1) 38.9 (2.5) 0.55
<32 8 (1.2) 15 (2.3) 0.26 0.52 (0.22-1.24) 0.48 (0.19–1.23)
32–36 53 (8.2) 60 (9.2) 0.86 (0.59–1.27) 0.78 (0.51–1.20)
>37
589 (90.6)
575 (88.5)

1
1
Mean birthweight, g§ 3,116 (549) 3.056 (620) 0.27
<2,000 20 (3.1) 32 (4.9) 0.36 0.62 (0.35–1.11) 0.66 (0.36–1.22)
2,000–2,999 235 (35.9) 236 (35.7) 0.99 (0.79–1.25) 1.01 (0.79–1.30)
3,000–3,999 372 (56.9) 371 (56.1) 1 1
>4,000
27 (4.1)
22 (3.3)

1.22 (0.69–2.19)
1.25 (0.65–2.39)
Stillbirth after 22 wk§
Yes 5 (0.8) 8 (1.2) 0.63 (0.20–1.93) 0.61 (0.18–2.07)
No
653 (99.2)
656 (98.8)
0.41
1
1
Congenital malformation
Yes 19 (2.9) 15 (2.2) 1.36 (0.68–2.74) 1.54 (0.68–3.49)
No
647 (97.1)
654 (97.8)
0.48
1
1
Admission to neonatal care§
Yes 53 (8.1) 55 (8.3) 0.97 (0.65–1.44) 1.03 (0.67–1.58)
No 605 (91.9) 609 (91.7) 0.88 1 1

*OR, odds ratio; CI, confidence interval. OR was adjusted for center, educational level, body mass index, and maternal age. Women infected before pregnancy were considered not infected during pregnancy.
†Of the 658 women who were infected, 650 had delivered a child after 22 weeks; 658 children were delivered by these women.
‡Of the 655 women who were not infected, 650 had delivered a child after 22 weeks; 664 children were delivered by these women.
§Miscarriage before 22 weeks was excluded.

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