Volume 16, Number 4—April 2010
Dispatch
Fluoroquinolone Resistance and Clostridium difficile, Germany
Nils Henning Zaiß
, Wolfgang Witte, and Ulrich Nübel
, Wolfgang Witte, and Ulrich NübelTable 2
Resistance to moxifloxacin and levofloxacin among the 5 PCR ribotypes of Clostridium difficile most common in Germany, 2008
| PCR ribotype (no.) | No. (%) isolates, resistant to moxifloxacin (MIC >4 mg/L) | No. (%) isolates, resistant to levofloxacin (MIC >4 mg/L) | Amino acid substitution |
|
|---|---|---|---|---|
| GyrA | GyrB | |||
| 001 (303) | 301 (99) | 301 (99) | Thr-82-Ile, Asp-71-Glu | |
| 078 (46) | 29 (63) | 30 (65) | Thr-82-Ile, Thr-82-Ala | Asp-426-Asn |
| 027 (51) | 51 (100) | 51 (100) | Thr-82-Ile | |
| 014 (21) | 2 (9) | 2 (9) | Thr-82-Ile | Glu-466-Lys |
| 046 (14) | 14 (100) | 14 (100) | Thr-82-Ile | |
