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Volume 16, Number 4—April 2010

Research

Influenza A Strain-Dependent Pathogenesis in Fatal H1N1 and H5N1 Subtype Infections of Mice

Mutien-Marie Garigliany, Adélite Habyarimana, Bénédicte Lambrecht, Els Van de Paar, Anne Cornet, Thierry van den Berg, and Daniel DesmechtComments to Author 
Author affiliations: University of Liège, Liège, Belgium (M.-M. Garigliany, E. Van de Paar, A. Cornet, D. Desmecht); Veterinary Agrochemical Center, Brussels, Belgium (A. Habyarimana, B. Lambrecht, T. van den Berg).

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Figure 5

Photomicrographs of liver, spleen, and lung sections from influenza virus A (H5N1)–infected mice at endpoint. Necrotic foci (arrows) scattered throughout the liver (A) (original magnification ×200) and spleen (B) (original magnification ×100) from subtype H5N1–infected mice (hematoxylin and eosin stain); these foci are absent from subtype H1N1–infected mouse livers. C) Necrotic foci in the liver stain periodic acid–Schiff (PAS)–positive (arrow), which suggests focal accumulation of glycogen (ori

Figure 5. Photomicrographs of liver, spleen, and lung sections from influenza virus A (H5N1)–infected mice at endpoint. Necrotic foci (arrows) scattered throughout the liver (A) (original magnification ×200) and spleen (B) (original magnification ×100) from subtype H5N1–infected mice (hematoxylin and eosin stain); these foci are absent from subtype H1N1–infected mouse livers. C) Necrotic foci in the liver stain periodic acid–Schiff (PAS)–positive (arrow), which suggests focal accumulation of glycogen (original magnification ×400). D) Numerous alveolar walls lined with PAS-stained hyaline membranes (arrows), suggestive of necrosis and desquamation of pneumocytes (original magnification ×1,000).

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