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Volume 16, Number 5—May 2010

Letter

Cross-Reactive Antibodies to Pandemic (H1N1) 2009 Virus, Singapore

Julian W. TangComments to Author , Paul A. Tambyah, Annelies Wilder-Smith, Kim-Yoong Puong, Robert Shaw, Ian G. Barr, and Kwai-Peng Chan
Author affiliations: National University Hospital, Singapore (J.W. Tang); National University of Singapore, Singapore (P.A. Tambyah, A. Wilder-Smith); Singapore General Hospital, Singapore (K.-Y. Puong, K.-P. Chan); World Health Organization Laboratory for Influenza Reference and Research, Melbourne, Victoria, Australia (R. Shaw, I. Barr)

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Table

Cross-reactive antibody titers to pandemic (H1N1) 2009 and seasonal influenza viruses for 50 persons, Singapore, May–October 2009*

Patient age, y/sex Laboratory 1 (Singapore General Hospital)
 Laboratory 2 (WHO, Melbourne)+
A/Auckland/1/2009
 A/Brisbane/59/2007
 A/Auckland/1/2009
 A/Brisbane/59/2007
HI† MN HI† MN HI‡ HI† HI‡
45/F <10 <10 <10 <10 <10 <10 <10
52/F <10 10 10 10 <10 10 <10
52/F <10 <10 10 <10 <10 <10 <10
52/F <10 <10 10 <10 <10 <10 <10
53/M <10 <10 10 <10 <10 <10 <10
53/F <10 <10 20 40 <10 <10 40
53/F <10 <10 160 80 <10 <10 160
53/M <10 <10 10 <10 <10 <10 <10
53/F <10 <10 160 320 <10 <10 160
53/F <10 <10 10 <10 <10 <10 <10
54/F <10 <10 10 <10 <10 <10 <10
54/M 10 <10 10 <10 <10 20 <10
55/F <10 <10 10 <10 <10 10 <10
55/F <10 <10 160 40 <10 <10 160
55/M <10 <10 10 <10 <10 <10 <10
56/F <10 <10 20 10 <10 <10 10
56/F <10 <10 80 80 <10 20 40
56/F <10 10 10 40 <10 <10 10
56/F <10 <10 10 <10 <10 <10 <10
57/M 10 20 40 40 20 20 <10
58/M <10 <10 20 20 <10 10 20
58/F <10 <10 40 20 <10 <10 80
59/M <10 <10 10 <10 <10 <10 <10
59/M <10 <10 20 20 20 20 10
59/F <10 <10 40 40 <10 <10 40
60/M <10 <10 80 40 <10 <10 80
60/M <10 <10 20 10 <10 <10 20
60/F 10 <10 10 <10 NR <10 <10
61/F 10 <10 10 <10 <10 10 <10
61/M 10 <10 160 160 <10 <10 320
61/M <10 <10 <10 <10 <10 <10 <10
61/F <10 <10 10 <10 <10 <10 <10
62/F <10 20 10 20 NR NR NR
62/F 10 10 80 20 <10 <10 40
62/F <10 <10 20 10 <10 20 40
62/F <10 <10 80 40 <10 <10 80
63/M <10 <10 80 40 <10 <10 80
63/F <10 <10 10 <10 <10 <10 <10
63/M <10 <10 40 20 <10 <10 20
63/M <10 <10 40 80 <10 <10 20
64/F 10 <10 20 10 <10 10 10
65/F 10 <10 10 <10 <10 20 <10
66/M <10 <10 <10 <10 <10 <10 <10
68/M <10 <10 40 80 <10 <10 40
71/F 10 10 10 20 <10 <10 <10
72/F <10 20 10 20 10 10 <10
75/M <10 <10 10 10 <10 20 <10
76/M <10 <10 40 20 <10 <10 40
78/F <10 10 10 20 <10 <10 <10
82/F 10 10 20 10 <10 20 <10

*WHO, World Health Organization; HI, hemagglutination inhibition; MN, microneutralization; NR, no results (because of insufficient serum).
†Tested with guinea pig erythrocytes.
‡Tested with turkey erythrocytes.

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