Emerging Infectious Disease ISSN: 1080-6059

Astrovirus Encephalitis in Boy with X-linked Agammaglobulinemia

Phenix-Lan Quan, Thor A. Wagner, Thomas Briese, Troy R. Torgerson, Mady Hornig, Alla Tashmukhamedova, Cadhla Firth, Gustavo Palacios, Ada Baisre-De-Leon, Christopher D. Paddock, Stephen K. Hutchison, Michael Egholm, Sherif R. Zaki, James E. Goldman, Hans D. Ochs, and W. Ian Lipkin

Author affiliations: Author affiliations: Columbia University, New York, New York, USA (P.-L. Quan, T. Briese, M. Hornig, A. Tashmukhamedova, G. Palacios, A. Baisre-De-Leon, J.E. Goldman, W.I. Lipkin); University of Washington, Seattle, Washington, USA (T.A. Wagner, T.R. Torgerson, H.D. Ochs); Seattle Children’s Hospital, Seattle (T.A. Wagner, T.R. Torgerson, H.D. Ochs); Pennsylvania State University, Pittsburgh, Pennsylvania, USA (C. Firth); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (C.D. Paddock, S.R. Zaki); and 454 Life Sciences, Branford, Connecticut, USA (S.K. Hutchison, M. Egholm)

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Figure 3

Phylogenetic analysis of full-length capsid protein sequences showing the relationship between human astrovirus Puget Sound (HAstV-PS) identified in brain of 15-year-old boy with X-linked agammaglobulinemia and encephalitis and other astroviruses. GenBank accession numbers in parentheses: MLB1 (FJ22245), VA1 (FJ973620), HAstV-1 (AB000295), HAstV-2 (L06802), HAstV-3 (DQ630763), HAstV-4 (AB025803), HAstV-5 (U15136), HAstV-6 (Z46658), HAstV-7 (Y08632), HAstV-8 (Z66541), MAstV (AY179509), OAstV (NC_

Figure 3. Phylogenetic analysis of full-length capsid protein sequences showing the relationship between human astrovirus Puget Sound (HAstV-PS) identified in brain of 15-year-old boy with X-linked agammaglobulinemia and encephalitis and other astroviruses. GenBank accession numbers in parentheses: MLB1 (FJ22245), VA1 (FJ973620), HAstV-1 (AB000295), HAstV-2 (L06802), HAstV-3 (DQ630763), HAstV-4 (AB025803), HAstV-5 (U15136), HAstV-6 (Z46658), HAstV-7 (Y08632), HAstV-8 (Z66541), MAstV (AY179509), OAstV (NC_002469), BatAstV (FJ571074), FAstV (AF056197), ChAstV (EU650331), PAstV (Y15938), ANV 1 (AB033998), ANV 2 (AB046864), TAstV 1 (Y15936), and TAstV 2 (AY769615). Bayesian posterior probability values >75% are shown at respective nodes. FAstV, feline astrovirus; ChAstV, cheetah astrovirus; PAstV, porcine astrovirus; OAstV, ovine astrovirus; MAstV, mink astrovirus; ANV, avian nephritis virus; TAstV, turkey astrovirus. Scale bar indicates number of amino acid substitutions per site.

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