Volume 16, Number 7—July 2010
Dispatch
Geographic Differences in Genetic Locus Linkages for Borrelia burgdorferi
Bridgit Travinsky, Jonas Bunikis, and Alan G. Barbour
Table
Linkages between ospC alleles and other loci in Borrelia burgdorferi strains*
| ospC | IGS1 | Geographic region* | Representative cultured isolate or tick sample† | IGS1-ospC associations‡ | ospA | IGS2 | MLST§ |
|---|---|---|---|---|---|---|---|
| A | 1 | 1, 2 | B31 | 45/52 | 1 | 1 | 1 |
| A | 11 | 2 | 2206617 | 4/4 | 22 | 1 | 55 |
| A | 10 | 3 | CA4, CA6 | 14/18 | 23 | 1 | 2 |
| Ba | 3 | 1 | 64b, B373 | 39/41 | 3 | 1 | 7,58,59 |
| Ba | 6 | 2 | 51405UT | 7/9 | 14 | 1 | 30 |
| Bb | 16 | 4 | ZS7 | – | 28 | – | 20 |
| C | 24 | 1 | JD1, BL515 | 10/10 | 8 | 5 | 11 |
| Da | 5 | 1 | 516113 | 13/14 | 5 | 4 | 38 |
| Db | 5 | 2 | 424404 | 13/15 | 18 | 7 | 51 |
| Db | 19 | 3 | CA11.2A | 16/16 | 27 | 4 | 70 |
| E | 9 | 1, 2 | N40, B348 | 17/19 | 9 | 1 | 19 |
| Fa | 17 | 1, 2, 3 | B156 | 61/64 | 3 | 4 | 8 |
| Fb | 18 | 2 | MI407 | 14/19 | 8 | 6 | – |
| Fc | 18 | 2 | 1469205 | 7/8 | 13 | 6 | 56 |
| G | 26 | 1 | 72a, MR616 | 10/11 | 9 | 4 | 14 |
| G | 22 | 2, 3 | 1468503 | 9/10 | 21 | 4 | 48,49 |
| Ha/Hb | 12 | 1 | B509/156a | 13/13 | 2 | 2 | 4 |
| Hb | 12 | 2 | 519014UT | 56/65 | 11 | 2 | 32 |
| Hb | 13 | 3 | CA92-0953 | 20/20 | 23 | 2 | 6 |
| Ia | 7 | 1 | B500, B331 | 12/16 | 7 | 4 | 15,16 |
| Ia | 7 | 2 | WI91-23 | 5/5 | 11 | 4 | 71 |
| Ib | 7 | 3 | CA92-1096 | – | 30 | 4 | 17 |
| J | 20 | 1, 2 | 118a | 3/5 | 8 | 4 | 34 |
| K | 2 | 1 | 297 | 67/68 | 2 | 2 | 3 |
| K | 14 | 2 | 149901 | 7/10 | 31 | 2 | – |
| L | 14 | 2 | 47703UT | 23/25 | 8 | 2 | 29 |
| M | 6 | 1 | 29805 | 4/4 | 2 | 3 | 12 |
| M | 6 | 2, 3 | CA92-1337 | 16/16 | 17 | 3 | 13 |
| N | 4 | 1 | MR661, 500203 | 41/41 | 4 | 10 | 9,36 |
| N | 23 | 2 | 51108 | 8/10 | 2 | 1 | 43 |
| Oa | 27 | 1 | 501427 | 1/1 | – | – | 54 |
| Ob | 6 | 2 | 2207807 | 6/7 | 2 | – | – |
| T | 28 | 1 | 23509 | 16/16 | 8 | 4 | 37 |
| T | 29 | 2 | 1476702 | 10/11 | 20 | 4 | 46 |
| Ua | 8 | 1 | 94a, B485 | 19/19 | 8 | 4 | 18 |
| Ua | 8 | 2 | 48802 | 4/4 | 16 | 4 | 47 |
| Ua | 17 | 2 | 2207116 | 4/4 | 12 | 10 | – |
| Ub | 30 | 2 | 426905 | 3/3 | 8 | 9 | – |
| A3 | 14 | 2 | 2206613 | 6/6 | 19 | 2 | – |
| B3 | 23 | 1, 2 | 2250201 | 3/3 | 17 | 1 | 57 |
| C3 | 17 | 2 | 50202 | 6/9 | 15 | 5 | – |
| D3 | 31 | 2 | 2150902 | 1/1 | – | – | – |
| E3 | 20 | 2 | 2127701 | 4/4 | 8 | 8 | 52 |
| E3 | 21 | 3 | HRT25 | 12/12 | 24 | – | – |
| E3 | 5 | 3 | LMR28 | 12/12 | 25 | – | – |
| F3 | 5 | 2 | 1456802 | 8/12 | 8 | 4 | – |
| H3 | 25 | 3 | CA8 | 37/40 | 26 | 4 | (72) |
| I3 | 17 | 3 | CA11, CA12 | 5/5 | 27 | 4 | – |
*Regions: 1, northeastern United States; 2, north-central United States; 3, northern California; 4, western Europe; osp, outer surface protein; IGS, intergenic spacer; MLST, multilocus sequence typing; –, MLST not determined.
†Tick samples (4) are indicated by italics; strains with genome sequences are indicated in boldface.
‡Number of tick extracts with the listed IGS1 locus (numerator)/number of extracts with the listed ospC allele (denominator).
§MLST from (4,12) or this study (in parentheses).
