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Volume 16, Number 7—July 2010

Dispatch

Vaccine-associated Paralytic Poliomyelitis in Immunodeficient Children, Iran, 1995–2008

Shohreh Shahmahmoodi, Setareh Mamishi, Asghar Aghamohammadi, Nessa Aghazadeh, Hamideh Tabatabaie, Mohammad Mehdi Gooya, Seyed Mohsen Zahraei, Taha Mousavi, Maryam Yousefi, Kobra Farrokhi, Masoud Mohammadpour, Mahmoud Reza Ashrafi, Rakhshandeh Nategh, and Nima ParvanehComments to Author 
Author affiliations: Tehran University of Medical Sciences, Tehran, Iran (S. Shahmahmoodi, S. Mamishi, A. Aghamohammadi, N. Aghazadeh, H. Tabatabaie, M. Yousefi, K. Farrokhi, M. Mohammadpour, R. Nategh, N. Parvaneh); Ministry of Health Center for Disease Control and Management, Tehran (M.M. Gooya, S.M. Zahraei, T. Mousavi); Pediatrics Center of Excellence, Tehran (S. Mamishi, A. Aghamohammadi, M. Mohammadpour, M.R. Ashrafi, N. Parvaneh)

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Table 2

Underlying primary immunodeficiency and immunologic findings for patients with vaccine-associated paralytic poliomyelitis, Iran, 1995–2008*

Patient no. Underlying immunodeficiency Leukocytes, cells/μL ALC, cells/μL CD3,† cells/μL CD4,† cells/μL CD8,† cells/μL CD19,† cells/μL IgG,‡ mg/dL IgM,‡ mg/dL IgA,‡ mg/dL
1 Undefined hypogammaglobulinemia NA NA NA NA NA NA NA NA NA
2 MHC class II deficiency 6,300 3,642 1,216 608 607 1,460 200 <10 <10
3 SCID 1,700 731 138 96 32 10 45 <10 <10
4 XLA 6,500 3,375 2,700 1,404 1,290 35 556 <10 <10
5 SCID 6,800 2,589 336 184 185 160 <10 <10 <10
6 XLA 8,500 4,000 2,760 1,920 835 40 20 58 25

*ALC, absolute lymphocyte count; Ig, immunoglobulin; NA, not available; MHC, major histocompatibility complex; SCID, severe combined immunodeficiency; XLA, X-linked agammaglobulinemia.
†Reference ranges for lymphocyte subpopulations: CD3, 1,900–5,900; CD4, 1,400–4,300; CD8, 500–1,700; CD19, 610–2,600 cells/μL.
‡Reference ranges for immunoglobulins: IgG, 661 ± 219; IgM, 54 ± 23; IgA, 37 ± 18.

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