Outbreak of Corynebacterium pseudodiphtheriticum Infection in Cystic Fibrosis Patients, France
Fadi Bittar1, Carole Cassagne1, Emmanuelle Bosdure, Nathalie Stremler, Jean-Christophe Dubus, Jacques Sarles, Martine Reynaud-Gaubert, Didier Raoult, and Jean-Marc Rolain
Author affiliations: Université de la Méditerranée, Marseille, France (F. Bittar, C. Cassagne, D. Raoult, J.-M. Rolain); Hôpital Timone, Marseille (E. Bosdure, N. Stremler, J.-C. Dubus, J. Sarles); Hôpital Sainte-Marguerite, Marseille (M. Reynaud-Gaubert)
Figure 1. Phylogenetic tree showing the position of Corynebacterium spp. isolated in patients with cystic fibrosis based on comparisons of the mass spectra obtained with matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry (A) and of sequences of the partial RNA polymerase β-subunit gene rpoB (B). For MALDI-TOF, a tree was constructed with Biotyper 2.0 software (Bruker Daltonics, Bremen, Germany) using Euclidean distance. The rpoB tree was constructed by the neighbor-joining method and a maximum likelihood-based distance algorithm and numbers on branches indicate the bootstrap values derived from 500 replications. *Reference strains (Mycobacterium tuberculosis H37Rv, C. propinquum CIP103792T, C. pseudodiphtheriticum CIP103420T).
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