Recurrent Granulibacter bethesdensis Infections and Chronic Granulomatous Disease
David E. Greenberg , Adam R. Shoffner, Adrian M. Zelazny, Michael E. Fenster, Kol A. Zarember, Frida Stock, Li Ding, Kimberly R. Marshall-Batty, Richard L. Wasserman, David F. Welch, Kishore Kanakabandi, Dan E. Sturdevant, Kimmo Virtaneva, Stephen F. Porcella, Patrick R. Murray, Harry L. Malech, and Steven M. Holland
Author affiliations: Author affiliations: National Institutes of Health, Bethesda, Maryland, USA (D.E. Greenberg, A.R. Shoffner, A.M. Zelazny, M.E. Fenster, K.A. Zarember, F. Stock, L. Ding, K.R. Marshall-Batty, P.R. Murray, H.L. Malech, S.M. Holland); University of Texas Southwestern Medical Center, Dallas, Texas, USA (R.L. Wasserman, D.F. Welch); Children's Medical Center, Dallas (D.F. Welch); Medical City Dallas Hospital, Dallas (D.F. Welch); National Institutes of Health, Hamilton, Montana, USA (K. Kanakabandi, D.E. Sturdevant, K. Virtaneva, S.F. Porcella)
Figure 2. Radiologic and pathologic findings of Granulibacter bethesdensis infection in patient 2, a 36-year-old man from the United States with X-linked chronic granulomatous disease. A) Contrast-enhanced computed tomography (CT) image at initial examination (December 2005), showing multiple lucencies in the spleen (arrows) and edema and stranding in the omentum and mesentery. B) Contrast-enhanced CT image (September 2006), showing resolution of splenic lesions after prolonged antimicrobial drug therapy. C) Contrast-enhanced CT image (April 2008), showing multiple lucencies in the spleen consistent with abscesses. D) Gross view of the sectioned spleen after splenectomy (April 2008), showing numerous abscesses.
The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.