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Volume 16, Number 9—September 2010

CME ACTIVITY

Recurrent Granulibacter bethesdensis Infections and Chronic Granulomatous Disease

David E. GreenbergComments to Author , Adam R. Shoffner, Adrian M. Zelazny, Michael E. Fenster, Kol A. Zarember, Frida Stock, Li Ding, Kimberly R. Marshall-Batty, Richard L. Wasserman, David F. Welch, Kishore Kanakabandi, Dan E. Sturdevant, Kimmo Virtaneva, Stephen F. Porcella, Patrick R. Murray, Harry L. Malech, and Steven M. Holland
Author affiliations: Author affiliations: National Institutes of Health, Bethesda, Maryland, USA (D.E. Greenberg, A.R. Shoffner, A.M. Zelazny, M.E. Fenster, K.A. Zarember, F. Stock, L. Ding, K.R. Marshall-Batty, P.R. Murray, H.L. Malech, S.M. Holland); University of Texas Southwestern Medical Center, Dallas, Texas, USA (R.L. Wasserman, D.F. Welch); Children's Medical Center, Dallas (D.F. Welch); Medical City Dallas Hospital, Dallas (D.F. Welch); National Institutes of Health, Hamilton, Montana, USA (K. Kanakabandi, D.E. Sturdevant, K. Virtaneva, S.F. Porcella)

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Figure 2

Radiologic and pathologic findings of Granulibacter bethesdensis infection in patient 2, a 36-year-old man from the United States with X-linked chronic granulomatous disease. A) Contrast-enhanced computed tomography (CT) image at initial examination (December 2005), showing multiple lucencies in the spleen (arrows) and edema and stranding in the omentum and mesentery. B) Contrast-enhanced CT image (September 2006), showing resolution of splenic lesions after prolonged antimicrobial drug therapy.

Figure 2. Radiologic and pathologic findings of Granulibacter bethesdensis infection in patient 2, a 36-year-old man from the United States with X-linked chronic granulomatous disease. A) Contrast-enhanced computed tomography (CT) image at initial examination (December 2005), showing multiple lucencies in the spleen (arrows) and edema and stranding in the omentum and mesentery. B) Contrast-enhanced CT image (September 2006), showing resolution of splenic lesions after prolonged antimicrobial drug therapy. C) Contrast-enhanced CT image (April 2008), showing multiple lucencies in the spleen consistent with abscesses. D) Gross view of the sectioned spleen after splenectomy (April 2008), showing numerous abscesses.

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