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Volume 17, Number 10—October 2011

Dispatch

Extensively Drug-Resistant Tuberculosis in Women, KwaZulu-Natal, South Africa

Max R. O’DonnellComments to Author , Jennifer Zelnick, Lise Werner, Iqbal Master, Marian Loveday, C. Robert Horsburgh, and Nesri Padayatchi
Author affiliations: Albert Einstein College of Medicine, Bronx, New York, USA (M.R. O’Donnell); Centre for AIDS Programme of Research in South Africa, Durban, South Africa (M.R. O’Donnell, L. Werner, N. Padayatchi); Touro College Graduate School of Social Work, New York, New York, USA (J. Zelnick); King George V Hospital, Sydenham, South Africa (I. Master); Medical Research Council, Cape Town, South Africa (M. Loveday); Boston University School of Public Health, Boston, Massachusetts, USA (C.R. Horsburgh)

Main Article

Table 1

Characteristics of 4,514 adults >18 years of age with MDR TB and XDR TB admitted to King George V Hospital, KwaZulu-Natal, South Africa, 2003–2008*

Characteristic† No. (%) women, n = 2,208 No. (%) men, n = 2,306 p value
HIV status
Positive 1,431 (64.8) 1,083 (47.0) <0.0001
Negative 394 (17.8) 642 (27.8)
Unknown
383 (17.3)
581 (25.2)

HIV positive and ART
Yes 731 (51.1) 465 (42.9) <0.0001
No
700 (48.9)
618 (57.1)

Health care worker
Yes 180 (8.2) 51 (2.2) <0.0001
No
2,028 (91.8)
2,255 (97.8)

Previous treatment
Yes 1,987 (95.4) 2,127 (94.4) 0.1305
No
96 (4.6)
127 (5.6)

Year of hospital admission
2003 188 (8.5) 278 (12.1) 0.0011‡
2004 195 (8.8) 234 (10.1)
2005 272 (12.3) 283 (12.3)
2006 358 (16.2) 350 (15.2)
2007 590 (26.7) 593 (25.7)
2008
605 (27.4)
568 (24.6)

Type of TB
MDR 1,987 (90.0) 2,150 (93.2) <0.0001
XDR 221 (10.0) 156 (6.8)

*MDR, multidrug-resistant; TB, tuberculosis; XDR, extensively drug-resistant; ART, antiretroviral therapy.
†Median patient age (interquartile range): women, 32 y (26–39 y); men, 36 y (30–44 y); p<0.0001.
‡Cochran-Armitage test for trend.

*MDR, multidrug-resistant; TB, tuberculosis; XDR, extensively drug-resistant; ART, antiretroviral therapy.
†Median patient age (interquartile range): women, 32 y (26–39 y); men, 36 y (30–44 y); p<0.0001.
‡Cochran-Armitage test for trend.

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