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Volume 17, Number 12—December 2011

Research

Hepatitis E Virus in Rats, Los Angeles, California, USA

Robert H. Purcell, Ronald E. Engle, Michael P. Rood, Yamina Kabrane-Lazizi1, Hanh T. Nguyen, Sugantha Govindarajan, Marisa St. Claire2, and Suzanne U. EmersonComments to Author 
Author affiliations: National Institutes of Health, Bethesda Maryland, USA (R.H. Purcell, R.E. Engle, Y. Kabrane-Lazizi, H.T. Nguyen, S.U. Emerson); Department of Public Health Services, Los Angeles, California, USA (M.P. Rood); Rancho Los Amigos Hospital, Downey, California, USA (S. Govindarajan); Bioqual, Inc., Rockville, Maryland, USA (M. St. Claire)

Main Article

Table 1

Results of testing for transmission of human and swine HEV to laboratory rats, Los Angeles, California, USA*

Inoculum
Genotype
ID50
No. injected
No. with HEV RNA or antibodies against HEV
Sar 55 1 103.8 2 0
Akluj-90 1 104.8 2 0
Kashi-87 1 108.1 2 0
Mex14 2 104.3 4 0
Meng 3 104.3§ 4 0
Meng 3 102.3 4 0

*HEV, hepatitis E virus. The 50% infectious dose (ID50) was administered intravenously.
†In human feces and titered in macaques.
‡Quantitative reverse transcription PCR titer.
§In pig feces and titered in pigs.
¶In macaque feces and titered in macaques.

Main Article

1Current affiliation: Embassy of France, Beijing, People’s Republic of China.

2Current affiliation: National Institutes of Health, Frederick, Maryland, USA.

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