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Volume 17, Number 12—December 2011


Hepatitis E Virus in Rats, Los Angeles, California, USA

Robert H. Purcell, Ronald E. Engle, Michael P. Rood, Yamina Kabrane-Lazizi1, Hanh T. Nguyen, Sugantha Govindarajan, Marisa St. Claire2, and Suzanne U. EmersonComments to Author 
Author affiliations: National Institutes of Health, Bethesda Maryland, USA (R.H. Purcell, R.E. Engle, Y. Kabrane-Lazizi, H.T. Nguyen, S.U. Emerson); Department of Public Health Services, Los Angeles, California, USA (M.P. Rood); Rancho Los Amigos Hospital, Downey, California, USA (S. Govindarajan); Bioqual, Inc., Rockville, Maryland, USA (M. St. Claire)

Main Article

Table 2

Rat HEV in serial fecal samples of experimentally infected laboratory rats, Los Angeles, California. USA*

Animal Day postinfection
7 9 11 13 15 17 19 21 23 25 27 29 31 33 35
Rat B76
Infectious† NT NT NT + + NT NT
RT-PCR NT NT NT + + + + + + NT NT
Serum antibody against HEV NT NT NT + + + +
Rat B84
Infectious† + + + + NT NT NT NT NT
RT-PCR + + + + + NT NT NT NT NT
Serum antibody against HEV + + + + + + + +

*HEV, hepatitis E virus; NT, not tested; –, negative; +, positive; RT-PCR, reverse transcription PCR.
†As measured by transmission to another rat.

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1Current affiliation: Embassy of France, Beijing, People’s Republic of China.

2Current affiliation: National Institutes of Health, Frederick, Maryland, USA.

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