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Volume 17, Number 12—December 2011

Research

Hepatitis E Virus in Rats, Los Angeles, California, USA

Robert H. Purcell, Ronald E. Engle, Michael P. Rood, Yamina Kabrane-Lazizi1, Hanh T. Nguyen, Sugantha Govindarajan, Marisa St. Claire2, and Suzanne U. EmersonComments to Author 
Author affiliations: National Institutes of Health, Bethesda Maryland, USA (R.H. Purcell, R.E. Engle, Y. Kabrane-Lazizi, H.T. Nguyen, S.U. Emerson); Department of Public Health Services, Los Angeles, California, USA (M.P. Rood); Rancho Los Amigos Hospital, Downey, California, USA (S. Govindarajan); Bioqual, Inc., Rockville, Maryland, USA (M. St. Claire)

Main Article

Table 3

Titers for HEV in samples from laboratory rats, Los Angeles, California, USA*

Sample type and source log10 ID50 log10 RT-PCR50
Feces
Rat B76† <1 3.4
Rat B84†
<1
3.4
Intestinal contents: Rat B182
Small intestine <3 4.9
Cecum <3 5.4
Colon
<3
4.9
Serum
Rat B182 ND 3.7
Rat B300 ND <2.2
Rat B350
3.7
4.7
Liver
Rat B182 4.7 7.2
Rat B300 4.2 5.7
Rat B350 6.2 7.7

*Values are per milliliter or per gram. HEV, hepatitis E virus; ID50, 50% infectious dose; RT-PCR50, 50% reverse transcription PCR titer; ND, not determined.
†Serum from wild rats was injected into laboratory rats B76 and B84. Samples from these 2 rats were serially passaged into other laboratory rats (wild rat → rat B76 → rat B300; wild rat → rat B84 → rat B182 → rat B350).

Main Article

1Current affiliation: Embassy of France, Beijing, People’s Republic of China.

2Current affiliation: National Institutes of Health, Frederick, Maryland, USA.

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