Human Cardioviruses, Meningitis, and Sudden Infant Death Syndrome in Children
Jan Felix Drexler, Sigrid Baumgarte, Monika Eschbach-Bludau, Arne Simon, Christoph Kemen, Udo Bode, Anna-Maria Eis-Hübinger, Burkhard Madea, and Christian Drosten
Author affiliations: University of Bonn Medical Centre, Bonn, Germany (J.F. Drexler, M. Eschbach-Bludau, A. Simon, U. Bode, A.-M. Eis-Hübinger, B. Madea, C. Drosten); Institute of Hygiene and the Environment, Hamburg, Germany (S. Baumgarte); Catholic Children's Hospital Wilhelmstift, Hamburg (C. Kemen)
Figure. Human cardiovirus phylogeny including novel viruses from myocardial tissue and cerebrospinal fluid. A) The 798-nt complete viral protein (VP) 1 phylogeny, with genotypes indicated to the right. Vilyuisk virus was used as an outgroup. B) The 802-nt partial 5′ untranslated region phylogeny of genotype 2 human cardioviruses. C) The 489-nt complete leader, complete VP4 and partial VP2 phylogeny of genotype 2 human cardioviruses. Neighbor-joining phylogenies were calculated with MEGA5 (www.megasoftware.net) by using a percentage nucleotide distance substitution model with complete deletion of gaps and 1,000 bootstrap reiterations for confidence testing. Only bootstrap values >70% are shown at node points. Scale bars indicate percentage nucleotide distance. Novel viruses from this study (sudden infant death syndrome [SIDS] 347/10 and cerebrospinal fluid [CSF] 07/03981) are shown in boldface. Reference viruses are given with GenBank accession number and strain name (when available).
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